血液透析滤过对尿毒症患者血清炎症指标与心脏结构的影响  

The effect of inflammatory biomarkers and cardiac structure in uremia patients treated by hemodiafiltration

作　　者：胡浩强[1] 刘国辉[1] 谢满静[1] 罗海凤[1] 

机构地区：[1]广东省东莞市人民医院肾内科,523059

出　　处：《中国医疗前沿》2013年第21期48-49,共2页China Healthcare Innovation

摘　　要：目的探讨持续血液透析滤过对尿毒症患者血清炎症指标与心脏结构的影响。方法随机选取我院59例尿毒症患者,观察组30例给予持续血液透析滤过治疗,对照组29例给予常规血液透析治疗。比较治疗前后的血清炎症指标与心脏结构之间的差异。结果经治疗,患者的血压降低明显、睡眠与食欲好转,观察组症状缓解情况优于对照组,但差异无统计学意义(P>0.05);治疗后CRP、IL-6、IL-8、TNF-α、Ab与Hb显著优于治疗前(P<0.05);观察组治疗后左房内径(LAD)、左心室舒张期内径(LVDd)、左心室收缩期内径(LVDs)、后室间隔舒张末期厚度(IVSTd)、左室收缩末期内径(LVPWTd)与左心射血分数(LVEF)显著优于治疗前,且均显著优于对照组,差异有统计学意义(P<0.05)。结论持续血液透析滤过治疗尿毒症的疗效佳,可显著改善患者的炎症状态与延缓心脏结构的改变。Objective To study the effect of inflammatory biomarkers and cardiac structure in uremia patients treated by hemodiafiltration. Methods 59 patients with uremia were randomly selected as the research objects, 30 cases of patients（observation group） were given hemodiafiltration treatment and 29 patients were given regular hemodialysis treatment（control group）. Serum inflammation index and the difference between cardiac structure before and after treatment were compared. Results After treatment, the patient’s high blood pressure, sleep and appetite were improved obviously, but there is no statistical significance between the observation group and the control group（P 〉0.05）; CRP, IL-6, IL-8, TNF-α, Ab and Hb after treatment were significantly better than before treatment（P 〈0.05）; LAD, LVDd, LVDs, IVSTd, LVPWTd and LVEF of observation group were significantly better than that of before treatment, and also significantly better than that of control group（P 〈0.05）. Conclusion The curative effect of hemodiafiltration treatment for uremia patients is well, it can significantly improve the patient’s state of inflammation and slow changes in the structure of the heart.

关 键 词：持续血液透析滤过 尿毒症 血清炎症指标 心脏结构 

分 类 号：R692.5[医药卫生—泌尿科学]