Liver Damage by the Interaction of Malathion with Cimetidine in Rat  

作　　者：Alba Delia Campafia Salcido Anthon ,Alvarez Arredondo 

机构地区：[1]Department of Pharmacology and Toxicology, Faculty of Medicine, Center of Research and Teaching in Health Sciences (C1DOCS),Autonomous University of Sinaloa, Culiacdn Sin 80030, Mexico

出　　处：《Journal of Life Sciences》2013年第10期1053-1056,共4页生命科学（英文版）

摘　　要：In this study the authors aimed to evaluate the oxidative stress enzymes indicative of liver damage in rats exposed to malathion （M）, subchronic form using cimetidine （C） and cimetidine plus malathion （M ＋ C）. Malathion, widely used organophosphorus insecticide worldwide, induces oxidative liver damage type; cimetidine is an antagonist of histamine H2-receptor, it has been shown to be an inhibitor of various CYP45o isoforms. Male Wistar rats weighing 200-250 g were studied, exposed to malathion orally for 3 weeks （0.15 mg/kg/day, 2 mg/kg/day, 15 mg/kg/day） and cimetidine 10 mg/kg/day. Malathion plus cimetidine affect susceptibility to oxidative stress and possibly modifies the antioxidant defense capacity directly or indirectly.

关 键 词：MALATHION CIMETIDINE lipid peroxidation MALONDIALDEHYDE ALT. 

分 类 号：TQ453.22[化学工程—农药化工] Q959.837[生物学—动物学]