影响人间充质干细胞数量的因素  

Influencing Factors on Numbers of Human Mesenchymal Stem Cells

作　　者：华杰[1] 龚健[1] 宋振顺[1] 

机构地区：[1]同济大学附属第十人民医院肝胆胰外科,上海200072

出　　处：《现代生物医学进展》2013年第36期7150-7152,7175,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81170436)

摘　　要：近年来,由于世界人口的老龄化及许多疾病的不可治愈性,成人间充质干细胞(hMSCs)用于细胞治疗越来越受到重视。虽然成人间充质干细胞可来源于骨髓、脂肪、脐血、脐带、胎盘、骨骼肌等,但由于其细胞数目较少,在临床运用之前必须依靠体外扩增来获取理想的细胞数量。本文拟搜索前期研究来探讨人间充质干细胞体外扩增期间影响细胞数目的因素,如供体的年龄、性别、组织来源选择及细胞接种密度,从而优化获取足量人间充质干细胞的过程,进而为今后临床干细胞治疗提供必要的理论基础。In recent years, human Mesenchymal Stem Cells （hMSCs） have gained more and more attentions due to a rise in the world＇s aging population and incurability of many disorders. Although adults MSCs can be derived from bone marrow, adipose, umbilical cord blood, umbilical cord, placenta and skeletal muscle, the cell numbers in these tissues are very low. Expansion in vitro is required to produce desired MSC numbers for clinical application. This review article will look at how some factors such as age and gender of donor, tissue of origin and seeding density will affect hMSCs expansion for clinical application by gathering previous study data so as to optimize the process of obtaining sufficient numbers of hMSCs and to provide necessary theoretical basis for fiarther clinical stem cell therapy

关 键 词：人间充质干细胞 年龄 性别 组织来源 接种密度 

分 类 号：R331[医药卫生—人体生理学] Q593[医药卫生—基础医学]