蛋白质组学在妊娠期高血压疾病中的研究进展  

Research Progress on Proteomics in Hypertensive Disorder Complicating Pregnancy

作　　者：朱文秀[1] 蔡雁[1] 邢宁宁[1] 

机构地区：[1]哈尔滨医科大学附属第四医院,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2013年第36期7194-7196,共3页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金(D200640)

摘　　要：蛋白质组学的兴起能快速筛选并鉴定疾病的特异性生物标志物,有助于研究妊娠期高血压疾病的病因、发生机制,通过特异性生物标志物进行早期诊断,从而改善母儿结局,降低母儿严重发病率和死亡率。本文综述近年来与妊娠期高血压疾病相关的蛋白质研究及其在妊娠期高血压疾病患者血液、脑脊液、尿液、羊水、滋养细胞中差异蛋白质谱的分析,为进一步研究提供思路。ABSTRACT： Appearance of proteomics technology can fleetly flit and reveal specificity biomarkers of disease,this will help to study the etiology, mechanisms and specific biomarkers of hypertensive disorder complicating pregnancy and and help early diagnosis, Improve the outcome of women and infants and reduce the severe morbidity of them.This article reviews the application of study technol- ogy of related proteins of hypertensive disorder complicating pregnancy on blood, Cerebrospinal fluid, urine, amniotic fluid, Sertoli cell, and in order to provide further research ideas.

关 键 词：蛋白质组 蛋白质组学 妊娠期高血压疾病 质谱技术 

分 类 号：R714.2[医药卫生—妇产科学]