6种介类中药对大鼠甲状腺肿大模型影响的实验研究  

Experimental Study of Six Testacean TCM "Endometriosis" Role on Goiter Model Rats

作　　者：彭倩倩[1] 洪寅[1] 廖广辉[1] 

机构地区：[1]浙江中医药大学药学院,杭州310053

出　　处：《浙江中医药大学学报》2013年第12期1429-1432,共4页Journal of Zhejiang Chinese Medical University

基　　金：浙江省教育厅科研项目(Y201223921)~~

摘　　要：[目的]观察牡蛎、石决明、瓦楞子、珍珠母、紫贝齿、蛤壳6种介类中药对大鼠甲状腺肿大的影响。[方法]72只健康SD大鼠随机分为9组:正常组、模型组、阳性组及6个介类中药组。每日灌胃丙硫氧嘧啶(0.15g·kg-1),连续造模10d,称量甲状腺湿重,酶联免疫法测血清T3、T4、TSH含量,观察光镜下甲状腺的形态变化。[结果]模型组大鼠较正常组甲状腺相对重量增加,T3、T4含量降低,且均有显著性差异(P<0.01),甲状腺滤泡上皮细胞增生明显;与模型组比较,牡蛎、蛤壳组使大鼠T3、T4含量均回升,且均有显著性差异(P<0.05);牡蛎、蛤壳组甲状腺滤泡上皮细胞增生不明显,其他4种介类中药组均有不同程度的增生。[结论]牡蛎、蛤壳对甲状腺肿模型大鼠甲状腺功能均有较好的改善作用。[Objective] To observe the effects of Oysters, Abalone shel , Concha arcae, Mother-of-pearl, Concha cypraeae, Clamshel , these six testacean TCM on the goiter rats. [Method] 72 healthy SD rats were randomly divided into nine groups：normal group, model group, positive group and six testacean TCM groups. Rats were given daily propylthiouracil （0.15 g·kg-1）, continuous modeling for 10d, weighing thyroid wet weight,assaying T3, T4 and TSH contents in serum by ELISA, observing the morphological changes of thyroid under light microscope. [Result] Rats in the model group compared with normal group in-creased the relative weight of thyroid, reduced the content of T3,T4, and there was a significant difference（ P〈0.01）, thyroid fol icular epithelial cellhyperplasia was obvious;compared with the model group, Oysters and Clamshel group made the content of T3,T4 in rat rebound, and there was a significant difference （P〈0.05）;Oyster and Clamshel group’s thyroid fol icular cellhyperplasia were not obvious, while the hyperplasia had different levels for the other 4 kinds of testacean TCM. [Conclusion] Oysters and Clamshel were better to improve the thyroid function of the goiter model rats.

关 键 词：介类中药 甲状腺肿大 大鼠 

分 类 号：R331[医药卫生—人体生理学]