铅和噪声联合作用对作业工人血SOD、MDA含量的影响  

The combined effects of lead and noise exposure on serum SOD and MDA levels

作　　者：李南春[1] 陈瑞梅[1] 陈朝军[1] 黄江洁[1] 

机构地区：[1]清远市疾病预防控制中心,511515

出　　处：《国际医药卫生导报》2014年第4期465-467,共3页International Medicine and Health Guidance News

基　　金：清远市科技计划项目（00092681320615009）

摘　　要：目的 探讨铅和噪声联合作用对工人的血清超氧化物歧化酶（SOD）、丙二醛（MDA）含量的影响.方法 选择年龄、工龄及接触噪声强度相近的A（铅和噪声联合作用组）、B（单纯噪声组）两组工人,测定血SOD、MDA含量,同时测定血铅含量,并比较两组数据差异.结果 A、B两组工人血SOD值分别为（65.2±16.3） U/ml、（63.8±13.9） U/ml,两组工人血SOD值无明显差异（P＞0.05）；A、B两组工人血MDA含量分别为（6.81±3.12）nmol/ml、（5.02±2.36）nmol/ml,两组工人血MDA含量差异有统计学意义（P＜0.05）.结论 铅和噪声联合作用可加重机体自由基损害和脂质过氧化.Objective To explore the combined effects of lead and noise exposure on serum SOD and MDA levels.Methods Workers in group A （lead and noise exposure） and group B （noise exposure） had matched age,length of working and intensity of noise.The serum SOD and MDA levels were detected and compared between two groups.Results The serum SOD levels of group A and group B were （65.2 ± 16.3）U/ml,（63.8 ± 13.9）U/ml respectively,without significant difference between two groups （P ＞ 0.05）.The serum MDA levels of group A and group B were （6.81 ± 3.12） nmol/ml,（5.02 ± 2.36） nmol/ml respectively,with significant difference between two groups （P ＜ 0.05）.Conclusion Lead combined with noise exposure may worsen free radical impairment and lipid peroxidation.

关 键 词：铅 噪声 联合作用 SOD MDA 

分 类 号：R131[医药卫生—劳动卫生]