肿瘤微环境的脾虚本质探讨  

The Spleen-Deficiency Nature of Tumor Microenvironment

作　　者：韩钦芮 符秀琼[2] 禹志领[2] 孙学刚[1] 

机构地区：[1]南方医科大学中医药学院 [2]香港浸会大学中医学院

出　　处：《中医杂志》2014年第4期292-294,298,共4页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81273621)

摘　　要：肿瘤是当今世界面临的最严重的公共卫生问题。肿瘤的免疫编辑理论补充、更新了肿瘤细胞中心论观点。肿瘤微环境促进了肿瘤从免疫相持到免疫逃逸的演变过程,慢性炎症和免疫抑制是其核心特征。多种肿瘤脾虚模型和病例均可见到慢性炎症和免疫抑制,脾虚因而可能是肿瘤微环境的核心病机。健脾中药能有效治疗肿瘤并改善肿瘤微环境相关细胞和分子功能,具有逆转肿瘤免疫逃逸的潜能,应用健脾中药通过调控肿瘤微环境抗癌可能是中医肿瘤防治新思路。Cancer is the most serious public health problem confronting the world today. The immunity-editing theory supplements and updates the tumor cell-centered theory. The tumor microenvironment promotes tumor immune stalemate to tumor immune escape. Chronic inflammation and immune suppression are the core features and can be seen in many tumor models and tumor cases with spleen deficiency pattern. So spleen deficiency may be the core pathogenesis of tumor microenvironment. Spleen-supplementing herbs are effective for cancer, based on improving the function of tumor microenvironment-related cells and molecules and potentially reversing the tumor immune escape. Regulating the tumor microenvironment with spleen-supplementing herbs may be a new idea in preventing and treating cancer in Chinese medicine.

关 键 词：肿瘤微环境 免疫编辑 脾虚 炎症 

分 类 号：R273[医药卫生—中西医结合]