鼠神经生长因子联合电子温针治疗糖尿病周围神经病变的疗效观察  

Clinical observation of mouse nerve growth factor combining with electronic temperature needle for treatment of diabetic peripheral neuropathy

作　　者：汤晓辉[1] 王玉容[2] 方向明[2] 叶文春[2] 

机构地区：[1]四川中医药高等专科学校,四川省绵阳市621000 [2]绵阳市中心医院内分泌科,四川省绵阳市621000

出　　处：《实用老年医学》2014年第1期26-28,32,共4页Practical Geriatrics

基　　金：四川省卫生厅课题(120306)

摘　　要：目的观察鼠神经生长因子联合电子温针治疗糖尿病周围神经病变(Diabetic perineuropathy,DPN)的临床疗效。方法 50例DPN患者随机分为A、B 2组,A组为鼠源性神经生长因子+电子温针治疗组,B组为单纯甲钴胺治疗组,观察两组治疗前后的临床疗效、运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)的改善情况、多伦多临床评分系统(Toronto clinical scoring system,TCSS)的评分情况及不良反应发生情况。结果 A组总有效率为88.00%,高于B组52.00%,差异具有统计学意义(P<0.01);2组治疗前后MNCV、SNCV较治疗前均改善,差异有统计学意义(P<0.05);治疗后A组改善情况优于B组,差异有统计学意义(P<0.05);2组治疗前后TCSS评分均明显降低,差异有统计学意义(P<0.01),治疗后A组改善情况优于B组,差异有统计学意义(P<0.05)。结论鼠神经生长因子联合电子温针治疗DPN变疗效确切,是治疗DPN的一种较好的方法,值得在临床上推广应用。Objective To observe the efficacy of the mouse nerve growth factor（mNGF） combining with electronic temperature needle in the treatment of diabetic peripheral neuropathy（DPN）. Methods 50 patients with DPN were ran- domly divided into two groups（ A and B group）.A group received NGF＋electronic temperature needle and B group received mecobalamin only.The clinical efficacy,the level of motor nerve conduction velocity（MNCV） and sensory nerve conduction velocity（SNCV） ,the TCSS were observed before and after treatment. Results The efficacy of A group was highter than that of B group（P〈0. 01）. The levels of MNCV and SNCV of A and B group were improved significantly （P〈0. 05）. The nerve conduction velocity of A group was higher than B group （ P〈0.05）, the TCSS of A and B group was decreased after treatment （P〈0. 01） ,especially in A group （P〈0. 05）. Conclusions Mouse nerve growth factor combining with elec- tronic temperature needle is safe and effective in the treatment of DPN.

关 键 词：神经生长因子 糖尿病周围神经病变 运动神经传导速度 感觉神经传导速度 电子温针 

分 类 号：R587.1[医药卫生—内分泌] R745[医药卫生—内科学]