纳米混悬剂的制备方法及给药途径研究进展  

Progress in research of preparation technologies and drug-delivery of nanosuspensions

作　　者：袁慧玲[1,2] 易加明 张彩云[1,2] 鲁传华[1,2] 陈卫东[1,2] 

机构地区：[1]安徽中医学院药学院,合肥230031 [2]安徽省中药研究与开发重点实验室,合肥230038

出　　处：《中国新药杂志》2014年第3期297-301,共5页Chinese Journal of New Drugs

基　　金：安徽省科技厅自然科学基金(10040606Q36);安徽省教育厅自然科学基金(KJ2012ZD09)

摘　　要：难溶性药物因生物利用度低等问题严重影响了其在医药领域的广泛应用。纳米混悬剂以制备方法简单、条件温和、不良反应小等优势在改善难溶药物的溶解度、增加药物溶出度、提高生物利用度等方面具有重要作用。本文对纳米混悬剂的制备方法及其给药途径进行了综述,并对影响粒径大小和药物生物利用度高低的因素进行了讨论,以期给更多研究者提供参考并供讨论。Poorly soluble drugs ability. Nanosuspension prepared under have seriously limited their widely use mild conditions with fewer side effects in medical field due to low bioavail- has important effects on the increase of the solubility, the dissolution rate and the bioavailability of drugs. In this review, we briefly introduced the prep- aration technology and the drug-delivery of nanosuspensions. At the same time we discussed the factors influencing the particle size and drug bioavailability, in order to provide references for more researchers.

关 键 词：纳米混悬剂 制备方法 给药途径 粒径 生物利用度 

分 类 号：R943[医药卫生—药剂学]