慢性腰背痛患者艾灸热敏现象的脑电机制初探  

EEG FEATURES OF HEAT-SENSITIZATION RESPONSES IN CHRONIC LOW BACK PAIN PATIENTS RECEIVING SUSPENDED MOXIBUSTION

作　　者：廖斐斐[1] 张潺[1] 边志杰[2] 谢丁一[3] 康明非[3] 李小俚[2,4] 万有[1] 陈日新[3] 伊鸣[1] 

机构地区：[1]北京大学神经科学研究所,北京100191 [2]燕山大学电子工程学院,秦皇岛066004 [3]江西中医药大学附属医院,南昌330006 [4]北京师范大学认知神经科学与学习国家重点实验室,北京100875

出　　处：《中国疼痛医学杂志》2013年第12期719-726,共8页Chinese Journal of Pain Medicine

基　　金：国家重点基础研究项目(2009CB522902;2013CB531905);;国家自然科学基金项目(81160453,31200835)

摘　　要：目的:初步揭示慢性腰背痛患者腰阳关穴艾灸热敏现象的脑电机制。方法:运用高密度脑电与神经计算技术,记录慢性腰背痛患者腰阳关穴灸前、灸中和灸后脑电信号并分析。结果:接受艾灸的25位患者中12位出现明显热敏现象。艾灸热敏现象伴随theta,alpha和beta频段功率谱密度增高。脑电地形图提示theta和beta频段PSD变化以额顶区为主,而alpha频段则为广泛性变化。此外,热敏现象伴随theta和beta频段相位一致性。而未出现热敏现象的患者以上变化均不明显。结论:研究提示,艾灸热敏现象伴随广泛脑电信号改变,脑电可能成为艾灸热敏现象的相对客观指标。其变化的行为相关性值得深入研究。Objective：To explore the EEG mechanisms of heat-sensitization responses in chronic low back pain patients receiving suspended moxibustion.Methods：EEG signals were recorded and analyzed with high-density EEG recording system and neurocomputation in chronic low back pain patients before,during and after suspended moxibustion at Yaoyangguan （DU3）.Results：We performed EEG in a group of patients with chronic low back pain before,during and after moxibustion treatment at DU3.12 out of 25 subjects experienced strong heat-sensitization during moxibustion,which were accompanied with increased power spectral densities at the theta,alpha and beta frequency bands.The scalp topographies of averaged power indicated that the theta and beta PSD changes were most obvious in fronto-central regions whereas those of the alpha band were more global.In addition,heat-sensitization induced increased phase coherence at the theta and beta ranges.In contrast,non-sensitized patients showed much less significant changes.Conclusion：These data were the first objective evidence suggesting the presence of heat-sensitization responses during suspended moxibustion,which were characterized by widespread oscillatory changes in scalp EEG.Their behavioural correlates are worthy of further investigation.

关 键 词：高密度脑电 艾灸 热敏 慢性腰背痛 

分 类 号：R246[医药卫生—针灸推拿学]