铜绿假单胞菌临床分布及耐药性分析  

Distribution and drug resistance of Pseudomonas aeruginosa in hospital

作　　者：郭洁[1] 唐新宁[1] 董亚静[1] 高原小雪[1] 荣芳[1] 

机构地区：[1]中国中医科学院望京医院检验科,北京100102

出　　处：《中国卫生检验杂志》2014年第2期273-275,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的了解医院近4年铜绿假单胞菌的临床分布特点及其对各种抗菌药物的耐药性,指导临床用药。方法回顾性分析2009年1月-2012年12月临床标本分离的铜绿假单胞菌的分布及其耐药性。结果 4年共分离铜绿假单胞菌1163株,占所有分离菌株的14.9%,其中痰液中分离976株占83.9%;分离菌虽然对大多数抗菌药物还有较好的敏感性,但对头孢他啶、头孢吡肟、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦、亚胺培南、美罗培南的耐药率还是呈上升趋势。结论铜绿假单胞菌是医院感染的常见致病菌之一,易产生多重耐药性,了解其临床分布和耐药性的变迁,可以为临床治疗提供资料,更好的控制铜绿假单胞菌的感染。Objective To investigate the clinical distribution characteristics and drug resistance of Pseudomonas aeruginosa from the hospital in recent 4 years, so as to guide the clinical rational use of drugs. Methods A retrospective analysis was per- formed on the distribution and drug resistance of P. aerugittosa isolates from various clinical specimens from Jan. 2009 to Dec. 2012. Results A total of 1163 strains of P. aeruginosa were isolated from the clinical specimens during the four years, ac- counting for 14.9% of all the isolates, including 976 （83.9%） isolates from the sputum specimens. The isolated bacteria were highly sensitive to most of the antimicrobial drugs, but showed an upward trend in drug resistance to Ceftazidime, Cefepime, Cefoperazone/Sulbactam, Piperacillin/Tazobactam, Imipenem, Meropenem. Conclusion The P. aeruginosa is one of the most common pathogens causing nosocomial infections and prone to produce muhidrug - resistance. Understanding the latest change of the clinical distribution and the drug resistance can contribute to control the P. aeruginosa infections.

关 键 词：铜绿假单胞菌 抗菌药物 耐药性 

分 类 号：R378.991[医药卫生—病原生物学]