肠道病毒71型致病机制研究进展  

Progress in pathogenesis of enterovirus 71

作　　者：柳楠[1] 吴志豪[1] 邱少富[1] 宋宏彬[1] 

机构地区：[1]军事医学科学院疾病预防控制所,北京100071

出　　处：《军事医学》2013年第12期955-959,共5页Military Medical Sciences

基　　金：国家自然科学基金资助项目(81171554)

摘　　要：肠道病毒71型(EV71)是引发手足口病的主要病原体之一,具有嗜神经性,可引起无菌性脑膜炎、脑干脑炎、肺水肿、心肌炎、急性弛缓性瘫痪等严重神经源性并发症,且病死率较高,严重威胁儿童身体健康和生命安全。目前,尚无有效针对EV71的抗病毒药物和预防性疫苗,具体致病机制仍不明确。该文综述了EV71的病原学、与宿主的相互作用以及体内传播方式等方面的最新进展,为EV71致病机制研究提供理论支持。Enterovirus 71(EV71) is one of the major pathogens of hand,foot and mouth disease(HFMD) among children and infants,which can also cause neurotropic complications including aseptic meningitis,brainstem encephalitis,neurogenic pulmonary edema,acute flaccid paralysis and other serious neurological diseases. EV71 infection is usually associated with higher mortality and regarded as a serious threat to public health. Currently,EV71 has no effective antiviral drugs and vaccines,and its specific pathogenesis is not clear. In this paper,the advances in the pathogenesis of EV71involving etiology,pathogen-host interactions and transmission in vivo are described.

关 键 词：肠道病毒71型 致病机制 免疫反应 炎症反应 

分 类 号：R373.2[医药卫生—病原生物学]