调Q和静态Er：YAG激光消融骨硬组织的研究  

Study on Ablation Hard Tissue Using Q-Switched Er： YAG Laser and Free-Running Er： YAG Lasers

作　　者：杨经纬[1] 江海河[1,2] 王礼[1] 王金涛[1] 吴先友[1,2] 

机构地区：[1]中国科学院安徽光学精密机械研究所,安徽合肥230031 [2]中国科学院合肥物质科学研究院医学物理与技术中心,安徽合肥230031

出　　处：《中国激光》2013年第B12期101-105,共5页Chinese Journal of Lasers

基　　金：国家自然科学基金（61275118）、国家自然科学基金委员会和中国工程物理研究院联合基金（U1230131）、中国科学院知识创新工程重点方向项目（KJCX2一EW.N07）

摘　　要：采用脉冲调QEr：YAG激光和脉冲静态Er：YAG激光分别对离体猪股骨组织进行了消融实验。测量出两种模式的Er：YAG激光对猪股骨的消融阈值范围分别为1．80～2．40J／cm。和3．46～5．00J／cm。，结果显示调QEr：YAG激光对离体猪股骨组织的消融阈值低。使用调Q激光与静态激光在重复率为3Hz，脉冲能量为200mJ，作用脉冲数为15次，分别辐照于离体猪股骨组织，利用扫描电子显微镜（sEM）观察骨组织消融出的坑状结构的形态变化。系统比较调QEr：YAG激光与静态Er=YAG激光消融骨组织在切口表面形貌、微结构变化等方面的优劣，同时在两种模式激光消融猪股骨组织过程中，使用热像仪观察两种激光模式的激光消融骨组织对组织周围的温度分布。实验结果表明调QEr：YAG激光消融猪股骨的消融效率高、切缝光滑且对周围组织细胞的热损伤小。因此，调QEr：YAG在猪股骨组织消融过程中具有显著的优势。Q-switched Er： YAG laser and free-running Er.＇YAG laser are used to study the laser ablation for the fresh porcine thighbones tissue in vitro. The ablation threshold range of the Q-switched laser and the free-running laser are 1.80~2.40 J/cm2 and 3.46~5.00 J/cm2, respectively. The results indicates that the ablation threshold of the Q-switched laser is lower. The fresh porcine thighbones tissue in vitro is irradiated by the two laser modes under the conditions of repetitive rate of 3 Hz, pulse energy of 200 mJ, and pulse number of 15 times. In addition, the morphologic changes of the tissue crater are observed by a scanning electron microscope （SEM）. The morphology and the microstructure of the incision surface of the tissue ablated by the two laser modes are compared. Meanwhile, in the process of laser ablation, temperature distribution of the irradiation region with the two lasers for the tissue is measured by thermal infrared imager. Results show that after laser ablation for the tissue by the Q-switched laser, the lancing is smooth and the thermal damage for the surrounding histocyte is slight. Thus, in the process of the laser ablation for the porcine thighbones tissue in vitro, the Q-switched laser has a significant advantage.

关 键 词：激光技术 Er YAG激光 调Q 骨硬组织 消融 

分 类 号：R318.51[医药卫生—生物医学工程]