狼疮性肾炎患者血清IL-10水平与狼疮疾病活动的关系  

Relationship of Serum Interleukin - 10 Level and Doseaes Activity in Lupus nephritis

作　　者：张涤华[1] 李幼姬[1] 黄凌虹[1] 叶任高[1] 梁柳琴[2] 孔庆瑜[1] 董玉英[2] 陈伟玲[2] 

机构地区：[1]中山医科大学附属第一医院肾内科,广州510080 [2]中山医科大学附属第一医院风湿内科,广州510080

出　　处：《中国中西医结合肾病杂志》2001年第1期17-19,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：中山医科大学211工程资助项目(No.98150)

摘　　要：目的：探讨狼疮肾炎（ＬＮ）患者血清白细胞介素－１０（ｓＩＬ—１０）水平改变与狼疮疾病活动的关系及意义。方法：应用酶联免疫法（ＥＬＩＳＴ）测定３８例ＬＮ患者和２２例健康志愿者ｓＩＬ－１０水平，同时应用狼疮疾病活动指数（ＳＬＥＤＡＩ）对 ＬＮ患者进行疾病活动评分，并对两者进行相关分析。结果： ＬＮ患者 ｓＩＬ－ １０水平明显较正常健康对照组高（１９．７±７．２ ｐｇ／ｍｌ ｖｓ １２．０±２，９ ｐｇ／ｍｌ，Ｐ＜０．０５），对ＳＬＥＤＡＩ与ｓＩＬ－１０水平进行Ｐｅａｒｓｏｎ直线相关分析，其相关系数ｒ＝０．１０５，Ｐ＝０．６０９（Ｐ＞０．０５），提示ＬＮ患者ＳＩＬ－１０水平与疾病活动指数无相关性。结论：ＬＮ患者血清白细胞介素－１０异常升高可能是一种内源性的异常而与狼疮疾病活动无明显相关性。Objective: To investigate the relationship and clinical significanes of serum interleukin - 10 (sIL - 10) level and disease activities in lupus nephritis(LN). Methods: 38 samples of LN were collected, and ELISA were used to detect the serum level of intereukin - 10. SLE disease activity index (SLEDAl) were evaluated in all patients. Correlation analysis were done sIL - 10 levels and SLEDAI. Results:sIL - 10 level of patient guoup was significantly higher than that of healthy control group (19.7 ±7.2 pg/ml vs 12.0 ±2.9 pg/ml, P<0.05). Pearson's linear correlation analysis indicated that corralation coefficient is 0. 105 (P > 0.05 ). sIL - 10 level had no correlation with SLEDAl in patients with LN. Conclusion: sIL - 10 level do not reflect the disease activities in LN, which indicate that abnormal production of IL - 10 in serum may be an intrinsic defect in patients with LN.

关 键 词：系统性红斑狼疮 狼疮肾炎 IL-10 免疫学 

分 类 号：R593.242[医药卫生—内科学]