活动性狼疮性肾炎中西医结合治疗163例  

Treatment of Active Lupus Nephritis with Integrated Traditional Chinese herbs and Modern medicine

作　　者：郭群英[1] 叶任高[1] 阳晓[1] 李幼姬[1] 汪涛[1] 

机构地区：[1]中山医科大学附属第一医院肾内科,广州510080

出　　处：《中国中西医结合肾病杂志》2001年第1期36-38,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：广东省中医药管理局资助(No.990073);中山医科大学211工程项目(No.98150)

摘　　要：目的：观察中西医结合治疗活动性狼疮性肾炎的疗效。方法：将３１９例活动性狼疮性肾炎分为西医组和中西医结合治疗组。西医组用激素标准疗程、环磷酰胺冲击治疗；中西医结合组在西医治疗的基础上辨证加用中药，观察临床有效率和副反应。结果：中西医结合治疗组有效率为 ８５， ３％，西医组为 ７３． ７ ％；中西组副反应发生率为３６．１％，西医组为７３．１％，Ｐ＜０．０５；中西组感染率及死亡率分别为２３．３ ％、８．０％，西医组为５３．２％和１６．７％，Ｐ值分别为小于０．０１和小于０．０５。中西组复发率为８．０％，西医组为２３．７％，Ｐ＜０．０５。结论：中西医结合治疗活动性狼疮性肾炎可以降低西药副作用发生率，减少感染并发症发生率，降低复发率和病死率。Objective:To investigate the clinical efficacy of treatment with integrated traditional Chinese herbs and modem medicine for patients with active Lupus Nephritis. Methods: Three hundred and nineteen patients with active Lupus nephritis were randomly divided into two groups: western medicine group(Contnd group)and integrated traditional Chinese herbs and modern medicine group(Herbs group). Results: The remission rates of the Herbs group and Control group were 85. 3 % and 73. 7% respectively. The adverse reaction rate, infection rate, mortality, and the rate of relapse were significantly higher in the Control group as compared with the Herbs group conclusion:Treatment with integrated traditional Chinese herbs arid modern medicine was an effective therapy for patients with active Lupus nephritis.

关 键 词：系统性红斑狼疮 中西医结合治疗 激素 环磷酰胺 

分 类 号：R593.242[医药卫生—内科学]