Synthesis and Herbicidal Activities of 2-Methylpropan-2-aminium O-Methyl 1-（Substituted Phenoxyacetoxy）alkylphosphonates  

作　　者：PENG Hao DENG Xiaoyan GAO Ling TAN Xiaosong HE Hongwu 

机构地区：[1]Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China

出　　处：《Chemical Research in Chinese Universities》2014年第1期82-86,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Basic Research Program of China（No.2010CB126100）, the National Key Technologies R＆D Progaram of China（No.2011BAE06B03）, the National Natural Science Foundation of China（No.21172090） and the Program for Changjiang Scholars and Innovative Research Team in University, China（No.IRT0953）.

摘　　要：A series of 2-methylpropan-2-aminium O-methyl 1-（substituted phenoxyacetoxy）alkylphosphonates （5a-5o） was selectively synthesized by reacting the corresponding O,O-dimethyl l-（substituted phenoxyacetoxy）-alkylphosphonates with an excess of 2-methylpropan-2-amine.The results of preliminary bioassays show that the title compounds exhibit moderate to good herbicidal activities against Brassica napus and Echinochloa crusgalli.Furthermore,compounds 5a-5j,which show much higher activities than compounds 5k-5o,were selected to further evaluate their post-emergence herbicidal activity at a dosage of 150 g/ha（l ha=10000 m2）.Especially,2-methylpropan-2-aminium O-methyl 1-[2-（4-chloro-2-methylphenoxy）acetoxy]butylphosphonate（5h） shows 100％ inhibitory effect on the growth of Brassica juncea and Amaranthus retroflexus,which is comparable with the commercial herbicide 2,4-dichlorophenoxy acetic acid（2,4-D）.A series of 2-methylpropan-2-aminium O-methyl 1-（substituted phenoxyacetoxy）alkylphosphonates （5a-5o） was selectively synthesized by reacting the corresponding O,O-dimethyl l-（substituted phenoxyacetoxy）-alkylphosphonates with an excess of 2-methylpropan-2-amine.The results of preliminary bioassays show that the title compounds exhibit moderate to good herbicidal activities against Brassica napus and Echinochloa crusgalli.Furthermore,compounds 5a-5j,which show much higher activities than compounds 5k-5o,were selected to further evaluate their post-emergence herbicidal activity at a dosage of 150 g/ha（l ha=10000 m2）.Especially,2-methylpropan-2-aminium O-methyl 1-[2-（4-chloro-2-methylphenoxy）acetoxy]butylphosphonate（5h） shows 100％ inhibitory effect on the growth of Brassica juncea and Amaranthus retroflexus,which is comparable with the commercial herbicide 2,4-dichlorophenoxy acetic acid（2,4-D）.

关 键 词：Herbicidal activity PHOSPHONATE 2-Methylpropan-2-aminium 

分 类 号：TQ457.2[化学工程—农药化工] TQ457.29