种子细胞在构建组织工程神经中的应用进展  

APPLICATION PROGRESS OF SEED CELLS IN TISSUE ENGINEERED NERVE

作　　者：李春波[1] 陈增淦[1] 陈统一[1] 张峰[1] 周建平[1] 

机构地区：[1]复旦大学附属中山医院骨科,上海200032

出　　处：《中国修复重建外科杂志》2014年第2期173-178,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：上海市科委重点攻关项目基金(1041195390)~~

摘　　要：目的综述雪旺细胞(Schwann cells,SCs)、干细胞及基因修饰细胞(genetically modified cells,GMCs)在周围神经损伤修复中的应用。方法查阅近年关于SCs、干细胞及GMCs的相关实验研究及临床应用文献,并进行综合分析。结果 SCs在周围神经缺损修复中起关键作用;诱导不同类型干细胞可分化为SCs,植入神经导管材料后可促进周围神经损伤修复;基因修饰技术能加强SCs或干细胞的功能,可能成为新的发展方向之一。结论组织工程神经研究虽已取得较大进步,但多局限于实验研究阶段,对于种子细胞在组织工程神经应用中的研究仍需继续深入。Objective To summarize the applications of Schwann cells （SCs）, stem cells, and genetically modified cells （GMCs） in repair of peripheral nerve defects. Methods The literature of original experimental study and clinical research related with SCs, stem cells, and GMCs was reviewed and analyzed. Results SCs play a key role in repair of peripheral nerve defects; the stem cells can be induced to differentiate into SCs, which can be implanted into nerve conduits to promote the repair of peripheral nerve defect; genetically modified technology can enhance the function of SCs and different stem cells, which has been regarded as a new option for tissue engineered nerve. Conclusion Although great progress has been made in tissue engineered nerve recently, mostly limited to the experimental stage. The research of seed cells in application of tissue engineered nerve need be studied deeply.

关 键 词：神经组织工程 雪旺细胞 干细胞 基因修饰细胞 神经导管 周围神经缺损 

分 类 号：R318[医药卫生—生物医学工程]