冠心病患者网膜素-1与高敏C反应蛋白的相关性分析  

Correlation Analysis of Serum Omentin-1 and Serum High Sensitive C-reactive Protein in Coronary Heart Disease

作　　者：刘海亮[1] 张慧霞[1] 张浩[1] 张瑞波[1] 杨丽娟[1] 刘淑婧[1] 

机构地区：[1]黄河三门峡医院心血管内科,河南省三门峡市472000

出　　处：《天津医药》2014年第2期135-137,共3页Tianjin Medical Journal

摘　　要：目的探讨网膜素-1(Omentin-1)、高敏C反应蛋白(hs-CRP)水平与冠心病的相关性。方法 68例冠心病患者分为不稳定型心绞痛(UAP)组36例,稳定型心绞痛(SAP)组32例,30例冠状动脉造影结果正常者为对照组。采用酶联免疫吸附法(ELISA)测定血清Omentin-1水平,增强免疫透射比浊法测定血清hs-CRP水平。结果冠心病患者血清Omentin-1水平低于对照组,hs-CRP水平高于对照组(均P<0.05);SAP组血清hs-CRP低于UAP组(P<0.05),而Omentin-1水平差异无统计学意义。单支、双支、三支病变组患者血清Omentin-1水平均低于对照组,血清hs-CRP水平均高于对照组(均P<0.05),单支、双支与三支病变组间Omentin-1、hs-CRP水平差异无统计学意义。冠心病患者血清Omentin-1与hs-CRP的水平呈负相关(P<0.01)。结论 Omentin-1、hs-CRP与冠心病存在一定的相关性,但并不能反映冠状动脉狭窄程度及范围。Objective To evaluate the correlation of Omentin-1, the high sensitivity C-reactive protein （hsCRP） and coronary heart disease （CHD）. Methods Sixty-eight patients with CHD were divided into the unstable angina pectoris （UAP） group （n=36）, stable angina pectoris （SAP） group （n=32）. And 30 normal subjects without CHD diagnosed by coronary arteriography （CAG） were served as the control group. The serum level of Omentin-1 was measured by enzyme linked immu-nosorbent assay （ELISA） and the serum level of hsCRP was measured by turbidmetric immunoassay. Results The serum level of Omentin-1 was significantly lower, but the serum level of hsCRP was significantly higher in CHD group than that of control group （P〈0.05）. The serum level of hsCRP was significantly lower in SAP group than that of UAP group （P〈0.05）. There was no significant difference in serum level of Omentin-1 between groups （P〈0.05）. The serum level of Omentin-1 was significantly lower in patients with single, double and three-vessel lesion group than that of control group, but the serum level of hsCRP was significantly higher in CHD group than that of control group （P〈0.05）. There were no significant differ-ence in serum levels of Omentin-1 and hs-CRP between single, double and three-vessel lesion groups （P〈0.05）. The se-rum level of Omentin-1 was negatively correlated with serum level of hsCRP （P〈0.01）. Conclusion The serum level of Omentin-1 and hsCRP may correlate with CHD, but which may not reflect the severity of artery stenosis.

关 键 词：冠心病 心绞痛 C反应蛋白质 网膜素-1 

分 类 号：R541.4[医药卫生—心血管疾病]