自体骨髓间充质干细胞移植治疗心肌梗死的进展  

Autologous bone marrow mesenchymal stem cells transplantation in treatment of myocardial infarction： recent advances

作　　者：胡星星[1] 朱庆磊[1] 

机构地区：[1]解放军总医院老年心血管病研究所,北京100853

出　　处：《中华老年多器官疾病杂志》2014年第1期71-75,共5页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家自然科学基金（81070200）

摘　　要：心肌梗死可引起心肌细胞的丢失，进而引起心脏功能的下降，是心力衰竭最主要的病因。骨髓间充质干细胞（BM—MSCs）是一类具有横向分化为各系统器官和组织能力的干细胞，能补充丢失的心肌细胞并通过旁分泌等机制增强心功能，为心肌梗死提供一种全新的治疗方法，极具发展潜力。本文对BM—MSCs的分离培养、诱导因素、移植以及临床研究等方面进行了综述。Myocardial infarction is the main cause of heart failure, causing the loss of myocardial ceils, and then declining the cardiac function. Bone marrow derived mesenchymal stem cells （BM-MSCs） are stem cells with capacity for self-renewal and potential to differentiate into a broad tissue distribution. BM-MSCs after transplantation can survive in the myocardium and then improve cardiac function through paracrine and other mechanisms. The cell transplantation provides a new approach for treatment of myocardial infarction and has great application potential. In this paper, we reviewed the current understanding of BM-MSCs isolation, induction, transplantation and recent clinical research on the therapy for cardiac diseases.

关 键 词：骨髓间充质干细胞 移植 心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]