股骨干大面积缺损多孔生物镁支架和骨科植入物的仿生力学  

Bionic mechanics of customized cellular bio-magnesium scaffolds for large-area defects of femoral shafts and implants for orthopaedics surgery

作　　者：赵为民[1] 李秉哲[2] 唐六丁[3] Peter Paul Müller 

机构地区：[1]河南科技大学第三附属医院-东方医院骨科,生物力学及生物医学研究所,河南省洛阳市471003 [2]河南科技大学生物力学及生物材料研究所,河南省洛阳市471003 [3]河南科技大学力学研究所,河南省洛阳市471003 [4]德国赫姆霍兹感染研究中心分子生物技术部,德国生物技术研究中心,德国D-38124 Braunschweig

出　　处：《中国组织工程研究》2014年第3期357-364,共8页Chinese Journal of Tissue Engineering Research

基　　金：2010年德国学术交流中心提供中国学者“赴德短期科研访问”、“前奖学金获得者再次访德”及“中德学者互换项目”基金,邀请函(Einladung,Invitation,A57-1.000-03/10/Koe)~~

摘　　要：背景:2010年德国学术交流中心经济上支持通讯作者,访问德国感染研究中心分子生物技术学部,合作项目《多孔生物镁支架的负重组织工程骨仿生技术基础及应用研究》项目,已完成该工作及生物镁仿生涂层基础实验。目的:研究股骨干大面积缺损多孔生物镁支架和新长入骨的仿生力学,以及板状骨科植入物和宿主骨的仿生力学,提出设计原则和发展方向。方法:以客户定制的多孔支架/新长入骨复合材料微体积元模型和板状植入物/宿主长骨层状复合材料微体积元模型为对象,利用弹性力学及体积定量多相分析等方法,提出各自的弹性模量混合法则,以及新长入骨(或宿主骨)的机械应力(刺激)公式。结果与结论:不同多孔支架材料的弹性模量和体积分数条件下,比较新长入骨的机械应力(刺激)和支架机械应力:①新长入骨/多孔金属(除多孔钽等外)支架复合材料强度明显高于原宿主骨,可能解决部分脱钙骨支架和人自体骨髓间充质干细胞复合物及其他非金属支架在植入人体早期缺乏一定力学强度的问题。②多孔支架材料的弹性模量和体积分数愈小,新长入骨所受到的机械刺激愈大。对于负重组织工程骨,特别是客户定制的股骨干、胫骨干、腓骨干等大面积缺损多孔支架,多孔生物镁支架是最佳选择。不同板状植入物的弹性模量、板厚度和应变,以及表面微结构和仿生涂层对宿主骨的机械刺激都有影响:①板状骨科植入物强度和刚性是最重要的。当植入板厚度愈小,弹性模量增大引起宿主骨的机械刺激减小愈不明显。②降低弹性模量的表面微结构对局部降低应力遮挡效应,保证宿主骨机械刺激,改善生物相容性,加强生物固定等是必要的。BACKGROUND： In 2010, the corresponding author was supported financially by German Academic Exchange Service, visiting the Department of Molecule Biotechnology, German Helmholtz Center of Infection Research, Braunschweig, Germany, creating the cooperation relation to research into the project ＂Fundament and Application of Biomimetic Technology for Customized Cellular Biomagnesium Scaffolds of Loaded Tissue Engineering Bones＂, finishing the present work and ＂Investigation on the Nanosize and Zeta（ξ）-potential of Polyelectrolytes for Biomimetic Coating Technology＂. OBJECTIVE： To focus on studying bionic mechanics between cellular scaffolds, customized for large area defects of femoral shafts, and new ingrown bones, as well as bionic mechanics between host bones and platelike implants for orthopaedics surgery, by means of elastic mechanics and stereo-quantitative metallographic analysis, and proposing the principle of bionic mechanics and the design criterion for above mentioned two types of problems, also some directions for research and development. METHODS： Different types of micro-volume models for two types of composites, i.e., cellular scaffolds/new-growing bones bio-composites, as well as plate-like implants/host bones layered composites were created, as well as different modulus mixing rules and mechanical stresses, i.e., stimuli, were presented, respectively. RESULTS AND CONCLUSION： Under the different modulus and volume fractions of scaffold materials, the mechanical stimuli of new ingrown bones are compared： （1） except cellular tantalum, the strength of cellular metallic scaffolds/new ingrown bones composites is obviously much higher than that of original host bones, to enable resolving the problem on insufficient mechanical strengths in early period of implanting the compound between partial demineralized bone scaffolds and autogenous human bone marrow mesenchymal stem cells, as well as other organic or inorganic scaffolds for tissue engineering. （2） The less the modu

关 键 词：生物材料 骨生物材料 客户定制 多孔生物镁支架 股骨干大面积缺损 板状骨科植入物 新长入骨 宿主骨 仿生力学 

分 类 号：R318[医药卫生—生物医学工程]