Mechanism underlying the protective effect of Kaixin Jieyu Fang on vascular depression following cerebral white matter damage  

作　　者：Ying Zhang Shijing Huang Yanyun Wang Junhua Pan Jun Zheng Xianhui Zhang Yuxia Chen Duojiao Li 

机构地区：[1]Guang’anmen Hospital,China Academy of Chinese Medical Sciences

出　　处：《Neural Regeneration Research》2014年第1期61-68,共8页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.30672696,81072801;the Natural Science Foundation of Beijing in China,No.7093129

摘　　要：The Chinese compound Kaixin fieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily intragastric administration of a suspension of Kaixin ]ieyu Fang powder. After 3, 7 and 21 days of treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased. These results indicate that Kaixin Jieyu Fang can alleviate cere- bral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/ Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression.The Chinese compound Kaixin fieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily intragastric administration of a suspension of Kaixin ]ieyu Fang powder. After 3, 7 and 21 days of treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased. These results indicate that Kaixin Jieyu Fang can alleviate cere- bral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/ Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression.

关 键 词：nerve regeneration vascular depression ligation of the bilateral common carotid arteries chronic cerebral ischemia white matter damage Kaixin ]ieyu Fang powder Bcl-2 Bax NSFC grant neural regeneration 

分 类 号：R285.5[医药卫生—中药学]