高血压患者颈动脉粥样硬化与其血清CD40/CD40L及MMP-9水平的关系  

Relationship between the Level of CD40/CD40L and MMP-9 in the Patients of Hypertension with Carotid Acherosderosis

作　　者：李建军[1] 马清峰[2] 张静[2] 熊亮[2] 

机构地区：[1]华中科技大学同济医学院附属梨园医院教学办公室,武汉430077 [2]华中科技大学同济医学院附属梨园医院检验科,武汉430077

出　　处：《微循环学杂志》2014年第1期32-34,I0002,共4页Chinese Journal of Microcirculation

基　　金：湖北省科技厅项目(2011CDB369)

摘　　要：高血压是诱发心脑血管性疾病的主要危险因素之一,高血压时湍流和剪切应力的增加可导致动脉内膜损伤,损伤部位易发生脂质沉积和血小板聚集,从而发生粥样硬化。颈动脉粥样硬化（CAS）最初被认为是一种大中动脉退行性、增生性、全身性疾病。之后研究发现,CAS 是一种与免疫和炎症反应密切相关的慢性疾病。作为重要炎症信号通路的白细胞分化抗原40（CD40）和154（CD154,又称CD40L）这一对受体-配体的相互作用参与了 CAS 的发生和发展[1]；基质金属蛋白酶（MMPs）是CAS斑块中炎症细胞的产物,亦与CAS的发生、发展密切相关[2]。本文通过对150例高血压患者颈动脉内膜中层厚度（CIMT）、硬化斑块指数（Plaque Index,PI ）和血清 CD40、CD40L 和MMP-9水平的测定,分析高血压患者 CAS 与CD40、CD40 L及MMP-9水平变化的关系,为防治、延缓CAS提供新的治疗靶点。Objective:To invistigate the relationship between the serum level of CD40,CD40Land MMP-9and carotid otherosclerosis(CAS)in the patients of hypertension.Method:The carotid intima-media thickness(CIMT)of 150cases patients with hypertension were measured by color Doppler ultrasound,Plaque index of patients with hypertension was divided into 0to 3level based on CIMT,plaque volume and plaque size,according to the thickening degree of CIMT,patients with hypertension were divided into normal group(11cases),thickening of the group(30cases)and plaque group(109cases);The serum CD40,CD40Land MMP-9level were measured by ELISA.To study the correlation of CIMT,PI and serum CD40,CD40Land MMP-9levels.Results:The serum level of CD40,CD40Land MMP-9in different group with hypertensive patients were significantly higher than the control group(P<0.05),and it was positively correlated with the thickening degree and PI levels of the CIMT with patients,the correlation coefficients were 0.989,0.996and 0.992 with thickening degree,the correlation coefficients were 0.983,0.991and 0.985with PI.Conclusion:The varying degrees of serum CD40,CD40Land MMP-9 were existed in hypertension patients with CAS.It may be a kind of method of the prevention and treatment of CAS by regulate the serum level of CD40,CD40Land MMP-9.

关 键 词：CD40 CD40L 颈动脉粥样硬化 高血压患者 MMP-9 水平变化 血清 颈动脉内膜中层厚度 心脑血管性疾病 

分 类 号：R541.4[医药卫生—心血管疾病]