^(18)F-FDG PET/CT显像对朗格罕细胞组织细胞增生症的价值探讨  

Value of ^(18)F-FDG PET/CT scans in detecting Langenhans cell histiocytosis

作　　者：黄盛才[1] 秦朝军[1] 马加强[1] 韦小林[1] 颜李梅[1] 

机构地区：[1]广西医科大学第一附属医院PET/CT中心,广西南宁530021

出　　处：《实用肿瘤杂志》2014年第1期73-77,共5页Journal of Practical Oncology

摘　　要：目的探讨18F-FDG PET/CT显像在化疗前朗格罕细胞组织细胞增生症累及的器官及化疗后疗效的评价。方法 14例1~14岁病理确诊为朗格罕细胞组织细胞增生症患儿均作PET/CT全身显像,其中3例是化疗前了解病变累及的器官;7例是化疗后评价疗效;4例为化疗前后对比,评价疗效。结果 3例化疗前的患儿双侧颈部淋巴结肿大并摄取18F-FDG增高,不同部位的骨质破坏并摄取18F-FDG增高;7例化疗后的患儿有6例肿瘤活性已完全灭活,1例原病灶部位仍有高度活性的肿瘤组织存在;4例化疗前后对比发现,2例肿瘤活性完全灭活,1例原病灶摄取18F-FDG减低,病情好转,1例病情加重,出现新发病灶。结论18F-FDG PET/CT显像在朗格罕细胞组织细胞增生症化疗前了解累及器官的范围及化疗后评价疗效是一种较好的无创方法。Objective To evaluate the value of18F-FDG PET/CT scans in detecting Langenhans cell histiocytosis （LCH） involved organs before chemotherapy and to investigate the treatment effect after chemotherapy. Methods Fourteen cases from 1 to 14 years with Langenhans cell histiocytosis confirmed by pathology,underwent whole body 18F-FDG PET/CT scans. Three cases had LCH involved organs detected before chemotherapy; 7 had curative effect evaluated after chemotherapy;4 had curative effect compared before and after chemotherapy. Results Three cases had lymph node enlargement and 18 F-FDG uptake increased on both sides of neck before chemotherapy,with bones destroyed and 18F-FDG uptake increased at different locations. Among 7 cases evaluated after chemotherapy, tumor activity was totally inactivated in 6 cases, only one still had high-activity tumour tissue. Among 4 cases with curative effect compared before and after chemotherapy, tumor activity in 2 cases was inactivated after chemotherapy, focal uptake of1 8F-FDG was reduced in 1 case and new focus was found in 1 case. Conclusion 18F-FDG PET/CT scan is valuable in detecting Langenhans cell histiocytosis involved organs before chemotherapy and evaluating curative effect after chemotherapy.

关 键 词：朗格罕细胞组织细胞增生症 药物疗法 正电子发射体层摄影术(PET) ^18F-氟代脱氧葡萄糖 治疗结果 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]