过氧化物酶增殖物活化受体γC161→T基因多态性与原发性高血压相关研究  

Association between gene polymorphism of peroxisome proliferator-activated receptor gamma C161→T and essential hypertension

作　　者：张扬[1] 邹晓译[1] 张双月[1] 刘双江[2] 王雪青[1] 翁倩[1] 邓丽红[1] 

机构地区：[1]秦皇岛市第一医院心内科,河北秦皇岛066000 [2]秦皇岛市第一医院急诊科,河北秦皇岛066000

出　　处：《中华实用诊断与治疗杂志》2014年第2期134-136,共3页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的探讨过氧化物酶增殖物活化受体γ(peroxisome proliferator-activated receptor gamma,PPARγ)C161→T基因多态性与原发性高血压的关系。方法 393例原发性高血压患者(高血压组)与405例体检健康者(对照组),应用聚合酶链反应-限制性片段长度多态性方法分析单核苷酸多态性位点,比较2组多态性频率。结果高血压组基因型分布及等位基因PPARγC161→T分布与对照组比较差异有统计学意义(P<0.05);高血压组T等位基因频率低于对照组(P<0.05)。结论 PPARγC161→T基因多态性与原发性高血压病有相关性。Abstract： Objective To explore the relationship between gene polymorphism of peroxisome proliferator-activated receptor gamma （PPARγ）Cl61→T and essential hypertension. Methods The gene polymorphism was analyzed by PCR- restriction fragment length polymorphism in 393 patients with essential hypertension and 405 healthy controls. The data of frequency were compared between two groups. Results There were significant differences in distribution of genotype and PPARγCl61→T allele between two groups （P〈0.05）. The frequency of T allele was lower in hypertensive patients than that in healthy controls （P 〈0.05）. Conclusions PPARγCl61→ T genetic polymorphism is correlated with essential hypertension.

关 键 词：高血压 过氧化物酶体增殖物激活受体Γ 多态性 限制性片断长度 

分 类 号：R544.11[医药卫生—心血管疾病]