干燥综合征患者唇腺活检、腮腺造影及唾液腺SPECT诊断价值的比较研究  

A comparison of sialography,labial minor salivary gland biopsy and technetium-99m sequential scintigraphy of salivary gland in the diagnosis of Sjgren syndrome

作　　者：刘慧[1] 赵春梅[2] 龚忠诚[1] 凌彬[1] 克热木·阿巴斯[1] 尹小朋[1] 林兆全[1] 

机构地区：[1]新疆医科大学第一附属医院口腔颌面部肿瘤外科,乌鲁木齐830054 [2]新疆医科大学第一附属医院风湿免疫科,乌鲁木齐830054

出　　处：《实用口腔医学杂志》2014年第1期66-69,共4页Journal of Practical Stomatology

摘　　要：目的:比较腮腺造影、唇腺活检及唾液腺SPECT(99mTcO-4唾液腺动态显像)在诊断干燥综合征(SS)中的价值。方法:纳入接受3项检查的患者59例,SS 41例,非SS 18例。分析比较各检查方法诊断SS的灵敏度、特异度、准确度及约登指数。结果:唇腺活检、腮腺造影、唾液腺SPECT的灵敏度分别为:63.4%、82.9%和92.7%;特异度分别为:94.4%、83.3%、88.9%;准确度为分别为72.9%、83.1%、91.5%。唇腺活检的灵敏度及准确度较其他2项检查低(P<0.05)。ROC曲线下面积分别为0.789 3±0.059 8、0.831 3±0.061 5和0.907 9±0.049 3(P<0.01);Youden指数分别为0.578、0.662和0.816。结论:唾液腺SPECT是诊断干燥综合征行之有效的检查方法。Objective： To evaluate the diagnostic reliability of sialography（ SG）, labial minor salivary gland biopsy（LMGB） and technetium -99m（ 99mTcO4- ） sequential scintigraphy（ single-photon emission computed tomography,SPECT） of salivary gland in the diagnosis of Sjtigren syndrome （SS）. Methods： The salivary gland of 59 patients, 41 with SS and 19 without SS, were examined by SG, LMGB and SPECT. The diagnostic sensitivity, specificity, accuracy and Youdan index of the examinations were compared. Results： The sensitivty of LMGB, SG and SPECT were 63.4%, 82.9% and 92.7% ; the specificity 94.4%, 83.3 % and 88.9% ; the accuracy 72.9%, 83.1% and 91.5% （ LMGB vs SG or SPECT, P 〈 O. 05 ） ; the area under ROC curve 0.789 3 ± 0.059 8, O. 831 3±0.061 5 and 0. 907 9± O. 049 3 （P 〈 O. O1 ） ; the Youden index 0.578, 0.662 and O. 816 respectively. Conclusion： SPECT is effec- tive in the diagnosis of Sjogren syndrome.

关 键 词：干燥综合征 腮腺造影 活检 99mTcO-4唾液腺动态显像(SPECT) 

分 类 号：R817.4[医药卫生—影像医学与核医学]