女性血清护骨素和转化生长因子β1与骨丢失率的关系  

Relationship between serum levels of OPG and TGF-β1 and bone loss rate in women

作　　者：龙海燕[1] 张红[2] 伍贤平[2] 廖二元[2] 谢辉[2] 罗湘杭[2] 伍西羽[2] 

机构地区：[1]湖南省娄底市中心医院内分泌科,湖南娄底417000 [2]中南大学湘雅二医院代谢内分泌研究所,长沙410011

出　　处：《中国骨质疏松杂志》2014年第1期5-11,共7页Chinese Journal of Osteoporosis

摘　　要：目的：护骨素（ OPG）和转化生长因子β1（ TGF-β1）与骨代谢密切相关。本研究调查女性血清OPG和TGF-β1水平与骨丢失率（ BLR）的关系，以及这两种细胞因子对BLR的影响。方法横断面研究465例健康成年女性，年龄35～80岁。测量血清OPG和TGF-β1水平，DXA骨密度仪测量腰椎、髋部和前臂远端的骨密度（ BMD）和BLR。结果各骨骼部位BLR与血清OPG呈负相关（r＝-0.122至-0.230， P＝0.007-0.000），与血清TGF-β1呈正相关（r＝0.245-0.365， P＝0.000）。调整年龄和BMI后，TGF-β1与腰椎和前臂超远端BLR的偏相关性仍然有显著意义。多元线性回归分析显示，OPG对BLR是一个负性决定因素，大约可以解释BLR变异的1.4％～3.7％；TGF-β1对BLR是一个正性决定因素，可以解释BLR变异的5.3％～13.3％。结论该研究揭示了成年女性循环中OPG和TGF-β1水平与骨丢失率的关系，提示TGF-β1和OPG水平变化与骨丢失率有关，TGF-β1可能是女性骨丢失率的独立决定因素。Objective To investigate the relationship between serum levels of OPG and TGF-β1 and bone loss rate （ BLR） in women, and to explore the effect of these 2 kinds of cytokines on BLR.Methods A cross-sectional study was performed.A total of 465 healthy adult women, aging from 35 to 80 years old were included in this study.The serum levels of OPG and TGF-β1 were determined.Bone mineral density （ BMD） and BLR of the lumbar vertebrae, the hip, and the distal forearm were detected using DXA.Results A negative correlation between BLR of all the parts and the serum level of OPG （ r=-0.122 to -0.230, all P=0.007-0.000） was observed, while a positive correlation between BLR and serum TGF-β1 （r=0.245-0.365, all P=0.000） existed.After adjusting for age and BMI, the significant correlation between serum TGF-β1 and BLR of the lumbar vertebrae and the ultradistal forearm still existed.Multiple linear regression analysis showed that serum OPG was a negative determinant of BLR, explaining 1.4-3.7%of BLR variation.Serum TGF-β1 was a positive determinant of BLR, which could explain 5.3-13.3%BLR variation.Conclusion This study has revealed the relationship between serum levels of OPG and TGF-β1 and BLR in adult women, which indicates that the changes of TGF-β1 and OPG levels are associated with BLR, and TGF-β1 may be an independent determinant for BLR in women.

关 键 词：护骨素 转化生长因子-Β1 骨丢失率 女性 骨质疏松 TGF-β1 

分 类 号：R589.5[医药卫生—内分泌]