机械应力、骨细胞凋亡和骨重建  

Mechanical stress,osteocyte apoptosis,and bone remodeling

作　　者：朱婧颖[1] 韩颖颖[1] 

机构地区：[1]上海理工大学医疗器械与食品学院,系统生物医学研究中心,上海200093

出　　处：《中国骨质疏松杂志》2014年第1期91-94,共4页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金青年基金资助项目(30900782);上海市重点学科建设项目(S30501)

摘　　要：骨细胞是骨中数量最丰富的细胞,有诸多重要作用。其作为骨组织的机械应力感受细胞,将机械载荷转化为体内生化反应过程,如细胞凋亡,同时产生一些调节成骨细胞和破骨细胞活性的因子和激素,共同参与骨组织的重建。骨细胞凋亡是一些骨代谢疾病的发病机制,可导致骨组织缺失或障碍性。本文简述了外界机械应力通过对成骨细胞和破骨细胞活性的调节,并刺激机体产生激素调节骨细胞凋亡,从而影响骨塑型和骨重建。通过机械应力对骨细胞凋亡调节的研究,为预防、治疗、诊断骨代谢疾病提供新的理论依据。Osteocytes are the most abundant cells in bone, which have various important functions.As the mechanical stress receptors in bone tissue, osteocytes can translate the mechanical load into intrinsic biochemical reaction process such as apoptosis, and meanwhile produce some kinds of cytokines and hormones regulating osteoblasts and osteoclasts, participating in the remodeling of bone tissues.Osteocyte apoptosis is the pathogenesis of some bone metabolic diseases, leading to bone loss or obstacle of bone tissues.This paper briefly introduces that the external mechanical stress stimulates the organism to generate hormonal regulation on osteocyte apoptosis by regulating the activity of osteoblasts and osteoclasts, thus influencing bone modeling and bone remodeling. The research on the regulation of mechanical stress to osteocyte apoptosis can provide a new theoretical basis for the prevention, treatment, and diagnosis of bone metabolic diseases.

关 键 词：骨细胞 细胞凋亡 机械应力 

分 类 号：R68[医药卫生—骨科学]