Ⅰ型自身免疫性肝炎患者抗Ro52抗体的检测及临床意义  

Antibody to Ro52 in patients with type I autoimmune hepatitis

作　　者：孙丽梅[1] 闫惠平[1] 冯霞[1] 王一鹏[1] 赵丹彤[1] 张海萍[1] 王熠[1] 马胤雪[1] 刘燕敏[1,2] 

机构地区：[1]首都医科大学附属北京佑安医院自身免疫性肝病临床研究中心,北京100069 [2]首都医科大学附属北京佑安医院肝病免疫科,北京100069

出　　处：《中国实验诊断学》2014年第2期236-239,共4页Chinese Journal of Laboratory Diagnosis

基　　金：首都卫生行业发展科研专项项目(2011-2018-05);佑安肝病艾滋病科研基金(BJYAH-2011-011)

摘　　要：目的 探讨Ⅰ型自身免疫性肝炎患者抗Ro52抗体的临床意义.方法 采用免疫印记法检测54例Ⅰ型自身免疫性肝炎（autoimmune hepatitis,AIH）患者血清中的抗Ro52抗体,根据检测结果分为抗Ro52抗体阳性组与阴性组,并对两组检测结果及临床资料进行回顾性分析.结果 54例Ⅰ型AIH患者中,抗Ro52抗体阳性20例（37％）.抗Ro52抗体阳性组与阴性组Ⅰ型AIH患者的抗核抗体（ANA分布主要见于滴度1∶320～1∶1000）.20例抗Ro52抗体阳性患者中,5例（25％）抗可溶性肝原（抗SLA/LP）抗体阳性；12例（60％）同时抗Ro60阳性.抗Ro52抗体阳性组出现肝病相关并发症的比例高于阴性组,但差别无统计学意义（65％vs.38.2％;x2 =3.613,P＞0.05）.抗Ro52抗体阳性组合并肝外自身免疫性疾病的比例显著高于阴性组（x2 =4.290,P=0.038）.抗Ro52抗体阳性组IgG水平显著高于阴性组（t=3.014,P=0.04）.结论 抗Ro52抗体阳性可提示AIH患者伴发肝内或肝外并发症几率升高；抗Ro52抗体可能与IgG共同作用,参与Ⅰ型AIH的发病.Objective To investigate thie significance of antibody to Ro52 in patients with type Ⅰ autoimmune hepatitis.Methods Fifty-five patients with type Ⅰ autoimmune hepatitis were detected anti-Ro52 by immunological blotting.According to anti-Ro52 results,the clinical features were compared between patients with and without anti-Ro52,respectively.Results Twenty patients had anti-Ro52,the rate was 37%.The titers of antinuclear antibody were 1 ∶ 320-1：1000.Of the twenty patients who had anti-Ro52,5 patients （25 %） had anti-soluble liver antigen/liver-pancreas antibody （anti-SLA/LP） ;12 patients （60%） had anti-Ro60.AIH Patients with anti-Ro52 had higher rate of liver disease related complications compared with the control group （65%vs.38.2% ;x2 =3.613,P=0.057）,but with little significance.AIH Patients with anti-Ro52 had higher rate of extrahepatic autoimmune diseases and IgG compared with the control group （x2 =4.290,P=0.038;t =3.014,P=0.04）.Conclusion AIH patients with anti-Ro52 may have higher rate of liver disease related complications.Anti-Ro52 and IgG may play a role in the development of AIH.

关 键 词：抗Ro52抗体 Ⅰ型自身免疫性肝炎 肝病相关并发症 肝外自身免疫性疾病 IgG 

分 类 号：R446.6[医药卫生—诊断学]