冠心病临床表现与勃起功能障碍相关性的研究  

Study of correlation of clinical expression of coronary heart disease and erectile dysfunction

作　　者：莫文宏[1,2] 杨帆[1,2] 何柳平[1,2] 

机构地区：[1]广西医科大学第四附属医院 [2]柳州市工人医院心血管内科,广西柳州545005

出　　处：《吉林医学》2014年第4期680-682,共3页Jilin Medical Journal

摘　　要：目的：根据冠心病CHD （受累单支或多支血管病变）的临床表现研究冠心病患者的勃起功能障碍（ED）患病率.方法：将285例CHD患者分为年龄匹配的3个组,每组95人：组I,ACS合并单支血管病变;组Ⅱ,ACS合并两支或三支血管病变（2、3-VD）;组Ⅲ,慢性冠状动脉综合征CCS.对照组为血管造影证实冠状动脉完全正常的可疑CAD患者.采用Gensini评分标准评价CHD,根据勃起功能国际指数（IIEF）判定ED.结果：组I 以Gensini评分表示的动脉粥样硬化负荷较组Ⅲ低（P〈0.05）,组I 的ED患病率较组Ⅲ低（P〈0.05）.对照组的ED患病率（24%）与组I 相似.组Ⅱ的ED发生率、IIEF及Gensini 评分与组I 相比差异有统计学意义（P〈0.05）,而与组Ⅲ相似.常规危险因素的数目和类型在各组间差异无统计学意义（P＞0.05）.与组I 和组Ⅱ比较,组Ⅲ的ED患者中,在CHD发病前已有性功能障碍者占93%,平均时间间隔24个月.Logistic回归分析显示,年龄（OR 2.503,95%,P〈0.005）、多支血管病变或单支血管;（OR 2.53,P〈0.005）以及CCS（OR 2.32,P〈0.005）.结论：ED患病率因CHD亚型不同而有所不同,与冠状动脉临床表现和CHD程度相关.在已确诊的CHD患者中,ED主要在患者CHD前平均2～3年发生.年龄是CHD并发ED的独立预测因素.Objective To investigate the ED prevalence of patients with coronary heart disease on the basis of clinical expression of CHD （ single or mtdtiveasel disease）. Method 285 patients with CHD were divided into three groups aeeording to the age There were 95 people in each group. Group I, ACS combined with single vessel disease ; Group II, ACS combined with multivessel disease （ 2/3 - VD） ; Group III, CCS （chronic coronary syndrome）. The contrast group was consisted of persons originally diagnosed with CAD, but later angiogra- phy diagnosis appeared normal. According to Gensini score standard, the ED was evaluated by IIEF. Results Atheresclerotie burden in Group I was lower than that in Group III （P 〈 0. 05 ）, and ED prevalence in Group i was lower than in Group III （P 〈 0. 05 ）. ED prevalence in contrast group（24% ） was similar to Group I. The incidence rate,IIEF and Gemini score between Group II and Group I had statistical significance （ P 〈 0.05 ）. Group II was similar to Group IIl in the above faetors. There were no significant difference in numbers and types of conventional risk factors （ P 〉 0.05 ）. Compared with group I and Group II, in Group III, the rate of patients with ED before CHD was 93%, average time interval was 24 months,logistic regression analysis showed that age （ OR 2. 503,95%, P 〈 O. 005 ） , single or multivessel dis- ease（ OR 2.53 ,P 〈0. 005 ）,CCS（ OR 2. 32, P 〈 0. 005 ）. Conclusion ED prevalence is different due to the different due to subtypes of CHD, and has connection with clinical expression of coronary artery and degrees of CHD. In diagnosed patients with CHD,the ED occurs two - three years before CHD. Age factor is an independent predictor in CHD combined with ED.

关 键 词：冠心病 勃起功能障碍 GENSINI评分 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]