普罗布考对稳定型心绞痛患者对比剂肾损害的预防作用  

Role of probucol in preventing contrast induced nephropathy in stable angina pectoris patients

作　　者：李景照[1,2,3] 赵凯[1] 党群[1] 

机构地区：[1]天津市南开医院心血管内科 [2]天津中医药大学研究生院,天津300100 [3]天津中医药大学

出　　处：《吉林医学》2014年第4期746-749,共4页Jilin Medical Journal

摘　　要：目的:探讨普罗布考能否降低稳定型心绞痛患者对比剂肾病(CIN)的发生率。方法:将拟行经皮冠状动脉介入(PCI)治疗的103例稳定型心绞痛患者随机分为基础治疗组(n=51)和普罗布考治疗组(n=52)。普罗布考组在常规治疗基础上加服普罗布考,术前3 d至术后3 d口服250 mg,3次/d。所有患者术前及术后连续3天检测血清肌酐(Scr)浓度,术前及术后24 h检测尿肾损伤分子-1(KIM-1)、尿白介素-18(IL-18)、尿中性粒细胞明胶酶相关性脂蛋白(NGAL)含量,并比较两组患者CIN的发生率。结果:两组共发生CIN 10例(9.71%),两组CIN的发病率差异有统计学意义(P<0.05)。结论:普罗布考对PCI治疗稳定型心绞痛患者对比剂肾损害有一定的预防作用,值得深入研究。Objective To study the prevention effects of probucol on contrast induced nephropathy （CIN）in stable angina pectoris pa- tients. Method One hundred and three stable angina pectoris inpatients were randomly divided into two groups ,basic treatment group （n =and probueol treatment group （n = 52,probueol 250 mg/d,3 times/d were used three days before angioplasty and three days after angio- plasty）. The levels of serum creafinine （Scr） ,urine KIM - 1 ,IL - 18 and bIGAL were detected before angioplasty and 24 hours after angio- plasty in patients of two groups. Then the incidence of CIN between two groups was compared. Results CIN occurred in 10 （9. 71% ） of the 103 patients. The incidence of CIN in the probucol treatment group was lower than basic treatment group The difference was statistically sig- nilicant（P 〈0. 05）. Conclusion For the treatment of patients who have stable angina pectoris with PCI,probucol have a preventive effect on renal damage. It is worthy of further study.

关 键 词：普罗布考 稳定型心绞痛 对比剂肾病 

分 类 号：R541.4[医药卫生—心血管疾病]