纳米石墨烯修饰电极电化学发光法测定盐酸氯丙嗪的研究  

Determination of Chlorpromazine Using Ru(bpy)_3^(2 +) Electrochemiluminescence Based on a Graphene Modified Glassy Carbon Electrode

作　　者：李焘[1] 谭学才[1] 胡琪[1] 吴佳雯[1] 方晓雪[1] 刘绍刚[1] 余会成[1] 黄在银[1] 

机构地区：[1]广西民族大学化学化工学院广西林产化学与工程重点实验室、广西高校化学与生物转化过程重点实验室,广西南宁530008

出　　处：《分析测试学报》2014年第2期212-216,共5页Journal of Instrumental Analysis

基　　金：国家自然科学基金(21065001,21365004);广西自然科学基金(2013GXNSFDA019006);广西教育厅科研项目(2013ZD019);广西民族大学研究生教育创新计划项目(gxun-chx2013t21)

摘　　要：基于盐酸氯丙嗪对联吡啶钌电化学发光的增敏作用,以石墨烯(Graphene)和Nafion复合膜修饰的玻碳电极(GCE)为工作电极,建立了一种直接测定盐酸氯丙嗪的电化学发光新方法。最佳实验条件下,盐酸氯丙嗪浓度在8.0×10-7~1.2×10-4mol/L范围内与其相对发光强度呈良好线性关系(r=0.998 8),且在该修饰电极上的检出限(S/N=3)为4.0×10-7mol/L。连续测定4.0×10-6mol/L盐酸氯丙嗪溶液11次,发光强度值的相对标准偏差(RSD)为1.4%,表明该修饰电极具有较好的重复性和灵敏度。盐酸氯丙嗪的加标回收率为93%~104%,RSD(n=5)为4.1%。将该方法应用于药片中盐酸氯丙嗪的检测,结果满意。Based on the enhancement of ECL intensity of Ru （bpy） 32 ＋ in the presence of chlorpromazine hydrochloride,a new ECL method was established for the determination of chlorpromazine hydrochloride at the glassy carbon electrode modified with composite film of graphene and nafion.Under the optimal experimental conditions,therelative ECL intensity had a good linear relationship with concentration of chlorpromazine hydrochloride in the range of 8.0 × 10-7-1.2 × 10-4 mol/L （r =0.998 8）,and the detection limit（S/N=3）was 4.0 × 10-7 mol/L.The RSD for 4.0 × 10-6mol/L chlorpromazine hydrochloride （n =11） was 1.4%.The results indicated that the graphene/nafion modified glassy carbon electrode had a good repeatability and sensitivity.The recoveries were in the range of 93%-104%,with RSD （n =5）of4.1%.The proposed method was applied in the analysis of chlorpromazine hydrochloride tablet with satisfactory results.

关 键 词：石墨烯 修饰电极 电致化学发光 盐酸氯丙嗪 三联吡啶钌 

分 类 号：O657.1[理学—分析化学] TQ460.72[理学—化学]