甘精胰岛素不同给药时间治疗1型糖尿病的疗效及安全性观察  

Observation on Efficacy and Safety of Insulin Glargine with Different Administration Time for Treating type 1 Diabetes

作　　者：王兰英[1] 厉红[1] 薛玲[2] 彭建霞[1] 严慧[1] 

机构地区：[1]河北省唐山市妇幼保健院儿科,河北唐山063000 [2]河北联合大学公共卫生学院,河北唐山063000

出　　处：《中国药业》2014年第4期30-31,共2页China Pharmaceuticals

摘　　要：目的评价不同时间皮下注射甘精胰岛素治疗1型糖尿病的疗效及安全性。方法选取内分泌科2008年1月至2013年3月收治的1型糖尿病患者35例,应用门冬胰岛素联合甘精胰岛素进行治疗。在甘精胰岛素不改变用量前提下,给药时间由22:00调整到18:00前后,比较时间调整前后3 d患者空腹血糖(FBG)、早中晚餐后2 h血糖(2hPG)和午餐前血糖的变化情况、门冬胰岛素的用量及午餐前患者低血糖事件发生情况。结果甘精胰岛素调整用药时间后,患者午餐前血糖调整至理想水平,FBG、午餐后2hPG下降显著(P<0.05),早餐后2hPG和晚餐后2hPG变化无显著差异(P>0.05);门冬胰岛素早餐前用量减少,午餐前和晚餐前用量增加;午餐前低血糖事件显著减少(P<0.05)。结论甘精胰岛素联合门冬胰岛素治疗1型糖尿病患者,在不改变甘精胰岛素用量情况下,给药时间由22:00调整为18:00,可平稳降低空腹血糖,减少午餐前低血糖的发生。Objective To evaluate the clinical efficacy and safety of insulin glargine by subcutaneous injection in different time for treating type 1 diabetes.Methods 35 cases of type 1 diabetes in the endocrinology department from Jan.2008 to Mar.2013 were treated with insulin aspart combined with insulin glargine,under the premise of unchanged insulin glargine dosage,the administration time of insulin glargine was changed from 22：00 to about 18：00.The fasting blood glucose （FBG）,2 h postprandial blood glucose （2hPG）,blood glucose before lunch,dosage of insulin aspart and occurrence of hypoglycemia event before lunch were compared between 3 d before and after the adjustment of administration time.Results After adjusting the insulin glargine＇s administration time,the blood sugar before lunch was adjusted to the ideal level,FBG and 2hPG after lunch were decreased significantly （P 〈 0.05）,but the changes of 2hPG after breakfast and after supper had no significant differences （P 〉 0.05）;the dosage of insulin aspart before breakfast was reduced,while which before lunch and dinner was increased;the hypoglycemia events before lunch were significantly decreased （P 〈 0.05）.Conclusion In the treatment of type Ⅰ diabetes by insulin glargine combined with insulin aspart,under the circumstance of unchanged dosage of insulin glargine,adjusting the administration time from 22：00 to 18：00 could smoothly and stably reduce FBG and reduce the occurrence of the hypoglycemia events before lunch.

关 键 词：甘精胰岛素 1型糖尿病 给药时间 血糖水平 安全性 

分 类 号：R969.4[医药卫生—药理学] R977.15[医药卫生—药学]