隐睾组织P53,Rb,nm23,C-berB-2基因研究  

Assay of Correlative Oncogene of Testicular Tissues in Cryptorchids

作　　者：刘国庆[1] 汪丽萱[1] 郑为[1] 赵夭望[1] 

机构地区：[1]湖南省儿童医院,湖南长沙410007

出　　处：《中国医师杂志》2000年第12期721-722,共2页Journal of Chinese Physician

摘　　要：为探讨隐睾患者患侧睾丸恶变的机理 ,采用免疫组织化学的方法 ,对 30例经临床确诊的先天性隐睾患者的患侧睾丸组织进行P53、Rb、nm2 3、C -berB - 2基因进行检测。结果发现nm2 3有 4例及C -berB - 2基因有 2例阳性结果 ,其中 1例腹腔型隐睾显示nm2 3、C -berB - 2基因两项均为阳性。结论 :提示隐睾患者患侧睾丸恶变可能与nm2 3、C -berB - 2基因变异有关 。The P53,Rb,nm23,C-berB-2 genes of testicular tissues were assayed with immunohistochemical method in 30 hereditary cryptorchids.The results indicate that nm23 of 4 cases and C-berB-2 of 2 cases were positively stained in 30 cases,and one of the 6 cases was both positively stained in an abdominal undescended testis.The findings suggest that aberrantion of nm23,C-berB-2 genes is associated with testicular neoplasms of retained testis,specifically abdominal undescended testis has trend to variation of correlative oncogenes of testicular tissues.

关 键 词：隐睾 睾丸肿瘤 基因 P53 NM23 C-BerB-2基因 

分 类 号：R697.2[医药卫生—泌尿科学]