诱导多能干细胞重编程方法的优化及其在航天医学中的应用展望  

Optimization of Reprogramming Methods for Induced Pluripotent Stem Cells and Prospect on Their Space Medicine Potential Application

作　　者：徐洪杰[1,2] 戴钟铨[2] 吴峰[2] 商澎[1] 李莹辉[1,2] 

机构地区：[1]西北工业大学生命学院空间生物实验模拟技术重点实验室,陕西西安710072 [2]中国航天员科研训练中心航天医学基础与应用国家重点实验室,北京100094

出　　处：《化学与生物工程》2014年第2期8-13,共6页Chemistry & Bioengineering

基　　金：国家重点基础研究发展计划(973计划)资助项目(2011CB707704);中国航天医学工程预先研究项目(2012SY54A1602);航天医学基础与应用国家重点实验室项目(SMFA09A08;SMFA12B02)

摘　　要：近年来,通过外源导入特定的转录因子,将体细胞重编程为类似胚胎干细胞(ESCs)潜能的诱导多能干细胞(iPSCs)掀起了干细胞研究的又一热潮,然而重编程效率低和安全性等问题严重阻碍着其临床应用。太空环境对成体干细胞分化潜能的影响是航天员生理变化的因素之一,具有类似ESCs全能性的iPSCs将为发育生理学及再生医学研究带来全新的视角。综述了iPSCs的研究进展,重点阐述提高安全性和重编程效率的方法和应用研究现状,并探讨了其在航天医学领域中的应用前景。Induced pluripotent stem cells（iPSCs）with characteristics identical to those of embryonic stem cells（ESCs） directly in vitro reprogrammed from somatic cells through transfacting a few specific transcription factors have captured great attention in research of somatic cells. However, low-efficiency reprogramming and safety seriously hamper development of clinical application. Effects of space environment on differentiation ac- tivity of multiple potent stem cells is one of reasons for astronants~ physiological changes. So iPSCs changes in space special conditons will provoke new insight for developmental biology and regeneration medicine. This re- view summarizes the researh progress of iPSCs, the method and application of improving reprogramming effi- ciency and safety,and the future in space medicine is prospected.

关 键 词：诱导多能干细胞 胚胎干细胞 重编程 再生医学 微重力 

分 类 号：R318[医药卫生—生物医学工程]