氨基磺酸/浓硫酸协同催化合成羧酸乙酯  

Facile synthesis of ethyl carboxylates via H_2NSO_3H/H_2SO_4 synergistic catalysis

作　　者：黄庆华[1] 陈明[1] 白雄雄[1] 古玲玲[1] 涂远明[1] 程传杰[1] 

机构地区：[1]江西科技师范大学化学化工学院,江西南昌330013

出　　处：《化学研究与应用》2014年第2期277-280,共4页Chemical Research and Application

基　　金：国家自然科学基金项目(21264008)资助;江西科技师范大学本科生创新科研基金项目资助

摘　　要：以肉桂酸和无水乙醇为原料、廉价的氨基磺酸/浓硫酸为协同催化剂、环己烷为带水剂,合成了肉桂乙酯,收率90.0%。反应的优化条件为:氨基磺酸/浓硫酸/肉桂酸/无水乙醇=1.9/1/9.1/31.8(物质的量之比),时间3 h。利用该优化条件,共合成了9种羧酸乙酯,包括芳香酸、脂肪酸、二元酸、不饱和酸的乙酯。该法突出的优点有:催化剂价廉易得且可重复使用、产率高、后处理简便。Ethyl cinnamate was efficiently synthesized in 90. 0% isolated yield by using cinnamic acid and anhydrous ethanol as sub- strates, and amino sulphonic acid/concentrated sulfuric acid as synergistic catalyst. The optimized reaction conditions were ： amino sulphonic acid/concentrated sulfuric acid/cinnamic acid/anhydrous ethanol = 1.9/1/9. 1/31.8 （ molar ratio）, reaction time 3 h. Other eight ethyl carboxylates were easily synthesized under the optimized conditions, including aryl, aliphatic, diacid, and unsatu- rated acid ethyl esters. The method featured recyclable and cheap synergistic catalysts, excellent isolated yields as well as very con- venient reaction workup.

关 键 词：协同催化 氨基磺酸 肉桂酸乙酯 羧酸乙酯 

分 类 号：O629.1[理学—有机化学]