氯化钾氯化钠注射液对静脉血管刺激性的动物实验研究  

Experiment research of vascular stimulation caused by potassium chloride and sodium chloride injection

作　　者：刘科[1] 韩丽[1] 邓亚红[1] 王干迷 杜俊蓉[1] 高青[1] 

机构地区：[1]四川大学华西药学院药理学系, 成都610041

出　　处：《中国实用护理杂志》2014年第5期36-39,共4页Chinese Journal of Practical Nursing

摘　　要：目的 研究氯化钾氯化钠注射液对血管的刺激性.方法 将16只新西兰兔随机分为2组各8只,按照临床常规补钾的最高剂量和最大输注速度,在兔耳缘静脉以同等滴速和同等输液量分别静脉滴注给予氯化钾氯化钠注射液或生理盐水,盲法观察用药局部的血管、周围组织及病理图片,对比2组对血管的刺激性.结果 氯化钾氯化钠注射液组与生理盐水组均未出现充血、肿胀、坏死等血管刺激性反应;亦未见炎性反应细胞浸润、细胞坏死等病理改变.结论 未发现氯化钾氯化钠注射液对动物模型静脉血管壁的刺激性.Objective To investigate the potential vascular stimulation of potassium chloride and sodium chloride injection.Methods Sixteen rabbits were divided equally into two groups：group one and group two,with six rabbits in each group.According to the highest dose and maximum infusion speed for routine potassium supplementation in clinic,potassium chloride and sodium chloride injection or 0.9% sodium chloride injection was administrated,respectively,at the same infusion speed and the same infusion volume via the marginal ear veins of rabbits.The vascular stimulation and the pathological changes of marginal ear vein and its surrounding tissue of rabbits were observed by the blinding method.Results Vascular stimulation,including hyperaemia,tumidness,necrosis and pathological changes,such as inflammatory cell infiltration and cellular necrosis,were not found in two groups.Conclusions Potassium chloride and sodium chloride injection has no stimulation to the wall of blood vessels.

关 键 词：氯化钾氯化钠注射液 生理盐水注射液 血管刺激性 

分 类 号：R965[医药卫生—药理学]