联用小剂量硝酸甘油、多巴胺、多巴酚丁胺治疗老年扩张型心肌病  

COMBINATION OF SMALL DOSES OF NITROGLYCERIN,DOPAMINE,AND DOBUTMINE IN THE TREATMENT FOR OLD PATIENTS WITH DILATED CARDIOMYOPATHY

作　　者：李刚[1] 马士新[2] 张奇志[2] 霍纲娣[2] 

机构地区：[1]南通市第三人民医院,南通市226006 [2]上海医科大学中山医院,200032

出　　处：《滨州医学院学报》2001年第1期12-13,共2页Journal of Binzhou Medical University

摘　　要：目的 :探讨不同药物对老年扩张型心肌病 (DCM)的短期疗效。方法 :43例老年 DCM患者中 ,对照组 2 0例给予地高辛、利尿剂、ACE抑制剂 ,口服硝酸酯治疗 ;治疗组 2 3例 ,在对照组用药基础上加用硝酸甘油 1 0 mg、多巴胺 60 mg、多巴酚丁胺 60 mg溶于 5%葡萄糖 50 0 ml中静滴 ,30 ml/h,每日 1次 ,疗程 1周。结果 :治疗组总有效率高于对照组 (P<0 .0 5) ,治疗组治疗后左室射血分数改善较对照组明显 (P<0 .0 5) ,两组治疗前后心率、收缩压无差异 (P>0 .0 5)。结果 :联用小剂量硝酸甘油、多巴胺、多巴酚丁胺治疗老年 DCM,短期观察安全、有效。Objective:To observe the short term therapeutic effect of different drugs in old Patients with dilated cardiomyopatgy(DCM).Methods:43 old Patients with DCM were divided into two groups.Group A(Control)was composed of 20 patients,who received digoxin,diuretics,ACEI,and oral isosorbide.Group B (Treatment) was composed of 23 patients,who received additional treatment with nitroglyceirn 10 mg,dopamine 60 mg,and dobutamine 60 mg dissolved in 5% GS 500 ml,30 ml/h intravenously,once daily for 1 week.Results:The total effective rate of group B was higher than that of group A ( P <0 05).The improvement of LVEF in group B was also better than that in group A ( P <0 05).There was no significant difference of heart rate and systolic blood pressure between two groups before and after treatment.Conclusions:The treatment of DCM in old patients by giving additional small doses of nitroglycerin,dopamine,and dobutamine was effective and safe in short term.

关 键 词：扩张型心肌病 心力衰竭 药物治疗 

分 类 号：R542.25[医药卫生—心血管疾病]