聚N-(2-羟丙基)甲基丙烯酰胺-肼屈嗪前药的合成及表征  

Synthesis and characterization of PHPMA-HYD macromolecule prodrug

作　　者：邢晓虎[1] 张娟[1] 张亚洲[1] 钟林桔 

机构地区：[1]西北大学应用化学研究所,陕西西安710069

出　　处：《西北大学学报（自然科学版）》2014年第1期57-60,共4页Journal of Northwest University（Natural Science Edition）

基　　金：陕西省教育厅科研计划基金资助项目(12JK0612)

摘　　要：研究聚N-(2-羟丙基)甲基丙烯酰胺-肼屈嗪(PHPMA-HYD)大分子前药的合成方法。以偶氮二异丁腈(AIBN)引发的聚合反应,制备药物载体PHPMA。然后以丁二酸酐为连接基团,将原药HYD连接在PHPMA上,得到了PHPMA-HYD大分子前药。对所得到的产物进行了紫外、FTIR、元素、DSC分析表征。检测结果显示前药中HYD的含量大于10.3%。该方法操作简单、易行,产率高。The method for synthesis of PHPMA-HYD macromolecule prodrug was studied. With AIBN as radi- cal initiator, PHPMA was synthesized by polymerization reaction. Then HYD was connected onto PHPMA with succinic anhydride as the linker. PHPMA-HYD macromolecule prodrug was synthesized. The products were characterized by UV, FTIR, DSC and elementary analyisis. The content of HYD in the prodrug is more than 10. 3%. The method has the advantages of usable, easv and high yield.

关 键 词：前药 N-(2-羟丙基)甲基丙烯酰胺 肼屈嗪 酰化反应 

分 类 号：O621.3[理学—有机化学]