冬凌草甲素抗突变性研究  

STUDY ON THE ANTIMUTAGENICTTY OF ORIDONIN

作　　者：杨胜利[1] 韩绍印[1] 张巧[2] 宋爱云[1] 丁兰萍[1] 宫亚欧[1] 张覃沐[3] 

机构地区：[1]河南医科大学食管癌研究室,河南郑州450052 [2]河南医科大学公共卫生学院 [3]河南省医学科学研究所

出　　处：《癌变．畸变．突变》2001年第1期8-10,共3页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：国家自然科学基金资助项目!(3970 0 178)

摘　　要：目的 :探讨冬凌草甲素的抗突变作用。方法 :采用Ames试验及小鼠骨髓嗜多染红细胞 (PCE)微核试验。结果 :冬凌草甲素在未加S9条件下 ,对TA98及TA10 0回复突变具有明显的抑制作用 ,其最高抑制率分别达 89 1%及 80 2 % ;对由环磷酰胺(CP)诱导的小鼠骨髓PCE微核发生率也有显著的拮抗作用 (P <0 .0 1)。结论Purpose: To study the antimutagenicity of Oridonin Methods: Ames test and micronucleus assay of polychromatic erythrocytes in mice bone marrow were used. Results: Oridonin could evidently inhibit the reverse mutation on Salmonella typhimuriun strains TA98 and TA100 without S9mix. The rates of maximum inhibition were 89.1% and 80.2% respectively. In addition, Oridonin could significantly reduce micronucleus frequencies induced by cyclophosphamide (P<0.01). Conclusion: Oridonin has significant antimutagenic effect.

关 键 词：冬凌草甲素 抗突变 AMES试验 微核试验 抗肿瘤作用 

分 类 号：R979.1[医药卫生—药品] R730.1[医药卫生—药学]