慢性荨麻疹自身抗体的表达情况及意义分析  

Analysis on the Expression and Significance of Autoantibodies in Chronic Urticaria

作　　者：夏耘[1] 

机构地区：[1]湖北省荆州市第一人民医院,湖北荆州434000

出　　处：《中国医学创新》2014年第4期8-10,共3页Medical Innovation of China

摘　　要：目的:对慢性荨麻疹自身抗体的表达情况及意义分析。方法:收集近期在本院治疗的慢性自身免疫性荨麻疹患者78例作为观察组,同时随机选择同期健康体检者78例作为对照,检测抗FcεRI抗体、抗甲状腺自身抗体(抗甲状腺过氧化物酶自身抗体与抗甲状腺球蛋白抗体)、抗幽门螺杆菌(HP)自身抗体、抗核抗体(ENA)、抗dsDNA抗体等自身抗体表达情况,并进行比较分析。结果:与对照组相比较,慢性荨麻疹患者FcεRI抗体、抗甲状腺抗体、HP抗体、抗dsDNA等自身抗体表达阳性率均明显升高,与对照组比较差异具有统计学意义,抗核抗体阳性率差异则不具有统计学意义。与对照组相比较,慢性荨麻疹患者FcεRI抗体、抗核抗体、抗dsDNA等自身抗体表达水平明显升高,比较差异具有统计学意义(P<0.05)。结论:慢性特发性荨麻疹的发病与其自身免疫背景有关,其血清内存在多种自身抗体异常表达,值得临床进一步研究应用。Objective：To analyze chronic urticaria autoantibody expression and significance. Method：In our hospital 78 patients with chronic autoimmune urticaria were selected as the observation group,and 78 healthy people were selected as control group. The detection of anti FcεRI antibody, anti thyroid antibodies（anti thyroid peroxidase antibodies and anti thyroglobulin antibody）,anti Helicobacter pylori（HP）antibodies,antinuclear antibody（ENA）,anti dsDNA antibody and other autoantibodies were compared. Result：Compared with the control group,FcεRI antibody,anti thyroid antibodies,HP antibody,dsDNA and other autoantibodies positive rate increased significantly,the difference was statistically significant,but he positive rate of anti nuclear antibodies difference was not statistically significant. Compared with the control group,the expression level of FcεRI antibodies,antinuclear antibodies,anti dsDNA antibodies was significantly higher,the differences were statistically significant（P〈0.05）. Conclusion：The incidence of chronic idiopathic urticaria and autoimmune background,its abnormal expression of serum autoantibodies,is worthy of further clinical application study.

关 键 词：慢性荨麻疹 自身抗体 IGE受体 自身免疫 FcεRI抗体 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]