介入治疗对胰腺癌乙型肝炎病毒感染患者的疗效分析  

Clinical efficacy of interventional therapy in pancreatic cancer patients with hepatitis B virus infection

作　　者：彭科[1] 赵渝[1] 凌康[2] 陈思宇[1] 曾秋[1] 钟巍[1] 

机构地区：[1]重庆医科大学附属第一医院血管外科,重庆400016 [2]重庆医科大学附属第一医院肝胆外科,重庆400016

出　　处：《中华医院感染学杂志》2014年第4期959-961,共3页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(81072887)

摘　　要：目的分析介入治疗对胰腺癌乙型肝炎病毒(HBV)感染患者的疗效,为改善患者的预后提供理论依据。方法选取医院2010年3月-2011年3月86例胰腺癌HBV感染患者,按照随机数字表法分为介入组及手术组,每组各43例,分别使用介入治疗及手术治疗,比较两组患者的临床疗效,并进行两年的随访,观察其6个月、1年及两年生存率,采用SPSS13.0软件对数据进行统计分析。结果治疗总有效率介入组为67.4%、手术组为37.2%,介入组治疗效果显著优于手术组;不良反应发生率介入组为32.6%、手术组为11.6%,介入组不良反应发生率显著高于手术组;治疗后介入组患者sTNFR-Ⅳ、IAP等指标显著低于手术组,差异有统计学意义(P<0.05);6个月、1、2年生存率介入组分别为97.7%、83.7%、34.9%,均显著高于手术组的88.4%、67.4%、16.3%,差异有统计学意义(P<0.05)。结论介入治疗可有效阻止胰腺癌肿瘤血管营养供给,影响肿瘤的浸润和转移,且能够显著改善患者的自身免疫功能,降低HBV感染带来的胰腺损伤,有利于保证其生存质量,同时,介入治疗较传统化疗具有更高的安全性和局部药物浓度,创伤小、操作简便,是临床治疗中晚期胰腺癌的有效方式。OBJECTIVE To analyze the clinical efficacy of interventional therapy in the pancreatic cancer patients with hepatitis B virus （HBV） infection so as to provide theoretical basis for improving the prognosis of patients. METHODS Totally 86 cases of pancreatic caner patients with HBV infection, who were treated in the hospital from Mar 2010 to Mar 2011, were enrolled in the study and randomly divided into the intervention group and the surgery group, with 43 cases in each, then the interventional therapy and the surgical procedures were respectively performed, the clinical efficacy was compared between the two groups, a two-year follow-up was conducted, the survival rates at six months, 1 year, and two years were observed, and the statistical analysis was performed with the use of SPSS13.0 software. RESULTS The total effective rate of treatment was 67. 4% in the intervention group, 37.2% in the surgery group, the therapeutic effect of the intervention group was significantly better than that of the surgery group; the incidence of adverse reactions of the intervention group was 32.6%, significantly higher than 11.6% of the surgery group; the levels of the indicators such as sTNFR-1V and IAP were significantly lower in the intervention group than in the surgery group, the differences were statistically significant（P^0.05） ; the six-month survival rate of the intervention group was 97.7%, significantly higher than 88.4% in the surgery groups the one-year survival rate of the intervention group was 83. 7%, significantly higher than 67.4% in the surgery group~ the two-year survival rate of the intervention group was 34.9%, significantly higher than 16.3% in the surgery group, with statistical significance （P% 0. 05）. CONCLUSION The interventional therapy can effectively prevent pancreatic tumor vascular supply of nutrients, affect the infiltration and metastasis of tumor,significantly improve the patient＇s own immune function, and reduce pancreatic injury caused by HBV infection so as to ensure the quality o

关 键 词：介入治疗 胰腺癌 疗效 安全性 

分 类 号：R512.62[医药卫生—内科学]