碳酸氢钠含漱液预防唇裂术后切口感染的临床研究  

Clinical effect of sodium bicarbonate gargle on prevention of wound infections after cleft lip and palate surgery

作　　者：佟晓敏[1] 李文博[1] 杨越云[1] 

机构地区：[1]沈阳医学院附属中心医院口腔科,辽宁沈阳110024

出　　处：《中华医院感染学杂志》2014年第4期983-985,共3页Chinese Journal of Nosocomiology

基　　金：辽宁省卫生厅规划基金项目(LW-2010B-029);辽宁省自然科学基金资助项目(20102220)

摘　　要：目的观察碳酸氢钠含漱液预防唇腭裂患儿术后切口感染的作用,以寻找降低唇裂术后切口感染的方法,提高唇裂手术成功率。方法选取2010年4月-2013年3月的67例唇腭裂手术患儿为研究对象,随机分为对照组32例、观察组35例,对照组和观察组术后含漱液分别使用生理盐水和碳酸氢钠进行预防切口感染,比较两组治疗后在切口感染及感染相关指标的差异性,采用SPSS13.0软件进行数据分析。结果对照组32例患儿中术后发生切口感染10例,感染率为31.25%,观察组35例患儿中发生切口感染5例,感染率为14.28%,两组比较差异有统计学意义(P<0.05);Ⅰ、Ⅲ级切口清洁度对照组患儿分别占31.25%、40.63%;观察组分别占54.29%、14.28%,两组比较差异有统计学意义(P<0.05);两组患儿感染相关性指标白细胞计数、超敏蛋白、白介素-6、肿瘤坏死因子-α含量在入院时比较,差异均无统计学意义,治疗1周后均有所改善,观察组较对照组改善更加显著,差异有统计学意义(P<0.05);创面愈合不良率观察组为2.86%、对照组为18.75%,两组比较差异有统计学意义(P<0.05)。结论碳酸氢钠含漱液可降低唇腭裂患儿术后切口感染发生率,且安全性好。OBJECTIVE To observe the clinical effect of sodium bicarbonate gargle on prevention of wound infections after cleft lip and palate surgery and seek measures to reduce incidence of the wound infections so as to improve success rate of the cleft lip and palate surgery. METHODS A total of 67 patients, who underwent the cleft lip and palate surgery from Apr 2010 to Mar 2013, were enrolled in the study and randomly divided into the control group with 32 cases and the observation group with 35 cases, then the control group was treated with normal saline for prevention of wound infections, while the observation group was given the sodium bicarbonate, the incidence of postoperative wound infections and the related indicators for infections were observed and compared between the two groups, and the statistical analysis was performed with the use of SPSS13.0 software. RESULTS The postoperative wound infections occurred in 10 of 32 cases of the control group with the infection rate of 31.25% and in 5 of 35 cases of the observation group with the infection rate of 14. 28%, the difference between the two groups was statistically significant （PO. 05）. The patients with the wound cleanliness of I accounted for 31. 25% in the control group, 54. 09%%o in the observation group the patients with the wound cleanliness of Ill accounted for 40.63% in the control group, 14.28% in the observation group, the differences between the two groups were statistically significant（P0.05）. The differences in the infection-related indicators such as the while blood celt （ WBC）, C-reactive protein （CRP）, interleukin -6 （IL-6）, and tumor necrosis factor- （TNF- a） on the admission were not statistically significant; all the cases have been improved through one-week treatment, and the improvement of the observation group was more significant than that of the control group, with statistical significance（P0.05）. The incidence of adverse wound healing was 2.86% in the observation group, 18.75% in the control group, the differe

关 键 词：碳酸氢钠含漱液 唇腭裂 切口感染 临床效果 

分 类 号：R619.3[医药卫生—外科学]