白前的镇痛、抗炎和抗血栓形成作用  

Study on Analgesic,Anti-inflammatory and Anti-thrombotic Effects of Rhizoma Cynanchi Stauntonii

作　　者：沈雅琴[1] 张明发[1] 朱自平[2] 王红武[2] 

机构地区：[1]上海美优制药有限公司,上海市201423 [2]陕西省中医药研究院中药所药理室,西安市710003

出　　处：《中国药房》2001年第1期15-16,共2页China Pharmacy

基　　金：国家自然科学基金资助项目!(39370838)

摘　　要：目的 :研究白前的镇痛、抗炎和抗血栓形成作用。方法 :采用常规的炎症和疼痛模型以及电刺激麻醉动物颈动脉的体内血栓形成模型。结果 :给小鼠ig(口服灌胃 )白前醇提物5g/kg 和15g/kg,能显著延长热痛刺激甩尾反应的潜伏期 ,减少由乙酸引起的扭体反应的次数 ,抑制二甲苯引起的耳肿、角叉菜胶引起的足跖肿胀。此外 ,它还能显著延长大鼠体内血栓形成时间和凝血时间。结论 :白前具有镇痛。OBJECTIVE:To study the analgesic,anti-inflammatory and anti-thrombotic effects of Rhizoma Cynanchi Stauntonii.METHODS:Experiments were carried out on conventional mouse models of inflammation and pain,and on a thrombotic model of using direct current continuously to stimulate the carotid artery on one side of the neck of anesthetic rat.RESULTS:Alcoholic extract of Rhizoma Cynanchi Stauntonii,in dosages of 5g herb/kg and 15g herb/kg ig,prolonged the latent period of tail flip response to hot water stimulation and reduced acetic acid-induced writhing frequency,and inhibited xylene-induced swelling of the ear and carrageenin-induced swelling of the planta.The extract,10g herb/kg ig,prolonged in vivo coagulative time and thrombotic time induced by electric stimulating artery in rats.CONCLUSION:Rhizoma Cynanchi Stauntonii has analgesic,anti-inflammatory and anti-thrombotic effects.

关 键 词：白前 抗炎药 镇痛药 抗血栓形成药 中药 药理 

分 类 号：R282.710.5[医药卫生—中药学] R285.5[医药卫生—中医学]