Effect of modified Taohongsiwu decoction on patients with chemotherapy-induced hand-foot syndrome  

作　　者：Changlin Zhao Jia Chen Bin Yu Xianlin Wu Congqi Dai Chang Zhou Xiaoyin Chen 

机构地区：[1]Department of Traditional Chinese Medicine,School of Medicine,Jinan University [2]Oncology Department,Clifford Hospital of Guangzhou University of Chinese Medicine

出　　处：《Journal of Traditional Chinese Medicine》2014年第1期10-14,共5页中医杂志（英文版）

基　　金：Supported by Doctoral Fund of the Ministry of Education 2010(No.20104401110003);National Natural Science Foundation of China(No.81273616 and 30973693);Guangdong Natural Science Foundation(No.S2013010013434)

摘　　要：OBJECTIVE:To observe the effect of the Traditional Chinese Medicine,modified Taohongsiwu decoction,versus pyridoxine on patients with hand-foot syndrome(HFS)from capecitabine,sorafenib,and gefitinib chemotherapy for gastric,lung,breast,colon,or rectal cancer.Also,to compare quality of life of patients in each group.METHODS:Patients were assigned randomly to group A or B.Group A was given modifiedTaohongsiwu decoction to soak hands and feet for 30 min,once daily.Group B was given 100 mg pyridoxine orally,twice daily.After a 2-week treatment,thetherapeutic effect was assessed by observing three major symptoms,including pain,ulceration,and muscular atrophy.This was assessed with the HFS-14 questionnaire.RESULTS:Significant differences were observed between the two groups in pain relief,and improvement of daily life,walking,and interpersonal communication(P<0.01).No significant differences in driving ability or interpersonal relationships were found.After 2 weeks,the effective rate was 88.3%in group A,which was significantly higher than the50%in group B(P=0.00).CONCLUSION:Modified Taohongsiwu decoction is effective in the treatment of patients with HFS.It improves patients'quality of life according to the HFS-14.OBJECTIVE： To observe the effect of the Traditional Chinese Medicine, modified Taohongsiwu decoc- tion, versus pyridoxine on patients with hand-foot syndrome（HFS） from capecitabine, sorafenib, and gefitinib chemotherapy for gastric, lung, breast, co- lon, or rectal cancer. Also, to compare quality of life of patients in each group. METHODS： Patients were assigned randomly to group A or B. Group A was given modifiedTaohong- siwu decoction to soak hands and feet for 30 min, once daily. Group B was given 100 mg pyridoxine orally, twice daily. After a 2-week treatment, thetherapeutic effect was assessed by observing three major symptoms, including pain, ulceration, and muscular atrophy. This was assessed with the HFS-14 questionnaire. RESULTS： Significant differences were observed be- tween the two groups in pain relief, and improve- ment of daily life, walking, and interpersonal com- munication（P0.01）. No significant differences in driving ability or interpersonal relationships were found. After 2 weeks, the effective rate was 88.3% in group A, which was significantly higher than the 50% in group B（P=0.00）. CONCLUSION： Modified Taohongsiwu decoction is effective in the treatment of patients with HFS. It improves patients＇ quality of life according to the HFS-14.

关 键 词：NEOPLASMS Hand-foot syndrome Mod-ifiedTaohongsiwu decoction Quality of life 

分 类 号：R259[医药卫生—中西医结合]