中国八省份一般人群血和尿液中砷水平及影响因素调查  被引量:36

Study of distribution and influencing factors of arsenic in whole blood and urine among population in 8 provinces in China

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作  者:丁春光[1] 潘亚娟[1] 张爱华[2] 吴邦华[2] 黄汉林[2] 朱醇[3] 刘德晔[3] 朱宝立[3] 许光 邵华 彭珊茁[5] 姜先龙 赵春香[7] 韩长城[8] 姬红蓉 余善法 张晓曦[11] 张龙连[12] 郑玉新[1] 闫慧芳[1] 

机构地区:[1]中国疾病预防控制中心职业卫生与中毒控制所化学安全与健康重点实验室,北京100050 [2]广东省职业病防治院 [3]江苏省疾病预防控制中心 [4]山东省职业病防治研究院 [5]辽宁省沈阳市第九人民医院检验科 [6]辽宁省丹东市卫生监督所 [7]河北省疾病预防控制中心职业卫生所 [8]河北医科大学公卫学院 [9]青海省疾病预防控制中心职业卫生所 [10]河南省职业病防治研究院 [11]北京市朝阳区疾病预防控制中心 [12]北京市丰台区疾病预防控制中心职业卫生所

出  处:《中华预防医学杂志》2014年第2期97-101,共5页Chinese Journal of Preventive Medicine

基  金:卫生部行业科研专项(200802020);国家科技支撑计划(2006BAI06B02)

摘  要:目的 调查我国一般人群血和尿砷水平,分析其影响因素.方法 于2009-2010年,采用整群随机抽样的方法在我国东部、西部和中部8个省份的24个市县抽取了18 120名6~ 60岁人群为研究对象,分别采集血液和尿液样品.应用电感耦合等离子体质谱法检测血和尿液中的砷水平,分析年龄、性别和区域以及生活方式对血砷和尿砷水平的影响.结果 我国一般人群全血中砷含量的几何均数为2.33μg/L;男性(2.35μg/L)高于女性(2.30 μg/L)(Z=-1.42,P<0.05);东、中、西部地区人群分别为2.94、1.30和0.98 μg/L(x2=643.22,P<0.05);吸烟人群(2.84 μg/L)高于不吸烟人群(2.27 μg/L)(Z=-6.28,P< 0.05);摄食海鲜人群(2.59 μg/L)高于不摄食海鲜人群(1.47 μg/L)(Z=-23.68,P<0.05).我国一般人群尿砷的几何均数为13.72 μg/L;男性(14.10 μg/L)高于女性(13.33 μg/L)(Z=-3.94,P<0.05);东、中和西部地区人群分别为14.14、16.02和9.57μg/L (x2 =353.89,P<0.05);吸烟人群(16.06 μg/L)高于不吸烟人群(13.70μg/L)(Z=-2.63,P<0.05);摄食海鲜人群(14.82 μg/L)高于不摄食海鲜人群(10.99μg/L)(Z=-3.20,P<0.05).血砷和尿砷水平相关系数为0.285,P<0.05.结论 我国一般人群血砷和尿砷水平存在性别及地区差异,同时与生活方式有关;血砷和尿砷水平呈正相关.Objective To evaluated the levels of arsenic (As) in blood and urine among general population in China and analyze its influencing factors.Methods A total of 18 120 subjects from general population aged 6-60 years were recruited from 24 districts in 8 provinces in eastern,central and western China mainland from 2009 to 2010,by cluster random sampling method.Blood samples and urine samples were collected,the information of the life-style was collected by questionnaire.Inductive coupled plasma mass spectrometry was applied to test the As level in the samples,and the distribution of As in blood and urine for different ages,genders,areas and life habits were then analyzed.Results The geometric mean (GM)of blood As concentration among general population was 2.33 μg/L;the GM of blood As in male(2.35 μg/L)was higher than and female(2.30 μg/L) (Z =-1.42,P < 0.05) ;from eastern,central to western China,the blood As level were 2.94,1.30 and 0.98 μg/L(x2 =643.22,P < 0.05),respectively; the GM in smokers (2.84 μg/L) was higher than non-smokers (2.27) (Z =-6.28,P < 0.05) ; the seafood consumer had a higher blood As level (2.59 μg/L) than people not consuming seafood (1.47 μg/L) (Z =-23.68,P <0.05).The urine As level of the whole population was 13.72 μg/L;while its GM in male(14.10 μg,/L)was higher than female(13.33 μg/L) (Z =-3.94,P < 0.05) ; the values from eastern,central to western China were 14.14,16.02 and 9.57 μg/L(x2 =353.89,P < 0.05),respectively; the level in smokers(16.06 μg/L)was higher than nonsmokers(13.70 μg/L) (Z =-2.63,P <0.05) ;the level in seafood consumers(14.82 μg/L) was higher than people not consuming seafood(10.99 μg/L) (Z =-3.20,P < 0.05).The blood As level had a positive correlation with urine As level (correlation coefficient:0.285,P < 0.05).Conclusion The As level in blood and urine varied by gender and area among general population in China,and related to lifestyles.There w

关 键 词: 血液 尿 横断面研究 电感耦合等离子体质谱 

分 类 号:R195[医药卫生—卫生统计学]

 

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