中国八省份一般人群尿中多环芳烃羟基代谢产物水平研究  

Polycyclic aromatic hydrocarbons monohydroxy metabolites level in urine of general population in eight provinces of China

作　　者：黄传峰[1] 张敬[1] 丁春光[1] 刘翠兰 王刚 宋新魁 黄汉林[3] 朱宝立[4] 邵华 赵春香[6] 韩长城[7] 彭珊茁[8] 姜先龙 余善法 姬红蓉 张晓曦[12] 孙冉[12] 郑玉新[1] 闫慧芳[1] 

机构地区：[1]中国疾病预防控制中心职业卫生与中毒控制所化学品安全与健康重点实验室,北京100050 [2]郑州市职业病防治所 [3]广东省职业病防治院 [4]江苏省疾病预防控制中心 [5]山东省职业病防治研究院 [6]河北省疾病预防控制中心职业卫生所 [7]河北医科大学公卫学院 [8]辽宁省沈阳市第九人民医院检验科 [9]辽宁省丹东市卫生监督所 [10]河南省职业病防治研究院 [11]青海省疾病预防控制中心职业卫生所 [12]北京市朝阳区疾病预防控制中心

出　　处：《中华预防医学杂志》2014年第2期102-108,共7页Chinese Journal of Preventive Medicine

基　　金：卫生部行业科研专项（200802020）;国家科技支撑计划（2006BAI06B02）

摘　　要：目的 调查我国一般人群尿液中多环芳烃羟基代谢产物2-羟基萘、1-羟基萘、3-羟基菲和1-羟基芘的水平,为进一步的研究工作提供基线资料.方法 2009至2010年在我国东部、西部和中部8个省份的24个市县,采用多阶段分层整群随机抽样的方法抽取了18 120名6～60岁人群为调查对象,对其生活环境和健康状况进行了问卷调查并收集尿液样品;用液相色谱质谱联用仪检测了4 680份尿液中2-羟基萘、1-羟基萘、3-羟基菲和1-羟基芘的水平,统计分析不同性别和年龄人群尿中上述代谢产物的分布情况.结果 我国一般人群尿中2-羟基萘、1-羟基萘、3-羟基菲和1-羟基芘的几何均数（95％ CI）分别为1.85（1.75～1.95）、1.55（1.50 ～1.61）、0.57（0.54 ～0.59）和0.82（0.78～0.85） μg/L,中位数分别为2.44、＜0.50、0.72和0.90 μg/L.6～12、13～16、17～20、21～30、31～45和46 ～60岁年龄组2-羟基萘的几何均数分别为1.60、1.56、1.69、2.23、1.91和1.86 μg/L（x2=17.90,P＜0.01）,1-羟基萘的几何均数分别为1.30、1.16、1.53、1.68、1.80和1.52 μg/L（x2=76.22,P＜0.01）,3-羟基菲的几何均数分别为0.78、0.76、0.55、0.42、0.50和0.99 μg/L（x2=66.48,P＜0.01）,1-羟基芘的几何均数分别为0.77、0.64、1.00、0.84、0.84和0.57μg/L（x2 =51.48,P＜0.01）,不同年龄组间4种代谢产物含量差异均有统计学意义.结论 我国一般人群尿中多环芳烃单羟基代谢产物的水平存在性别、年龄差异,本研究为进一步开展多环芳烃代谢产物生物监测提供了基础数据.Objective To assess the levels of polycyclic aromatic hydrocarbons monohydroxy metabolites in urine of general population in China among 8 provinces,provide the baseline of the metabolites in the general population.Methods From 2009 to 2010,18 120 subjects of general population aged 6-60 years old were recruited from 24 areas among 8 provinces in east,west and central areas of China mainland by cluster random sampling.The information of the living environment and health condition were collected by questionnaire and spot urine samples were collected,4 680 urine samples were analysed by high performance liquid chromatography with tandem mass spectrometry,and monohydroxy metabolites distribuation in urine among groups of gender and ages were analysed.Results Geometric means （GM） of 2-naphthol,1-naphthol,3-phenanthrol and 1-hydroxypyrene concentration in urine （95％ CI） were 1.85 （1.75-1.95）,1.55（1.50-1.61）,0.57（0.54-0.59） and 0.82（0.78-0.85） μg/L,respectively;and median are 2.44,＜ 0.50,0.72 and 0.90 μg/L,respectively.The concentration between male and female were significantly different（P ＜0.01）,and the concentration among the groups of population were significantly different（P ＜ 0.01）,the GM of 2-naphthol among the groups of population aged 6-12,13-16,17-20,21-30,31-45 and 46-60 years old were 1.60,1.56,1.69,2.23,1.91 and 1.86 μg/L（x2 =17.90,P ＜ 0.01）,the GM of 1-naphthol in the groups were 1.30,1.16,1.53,1.68,1.80 and 1.52 μg/L（x2 =76.22,P ＜ 0.01）,the GM of 3-phenanthrol in the groups were 0.78,0.76,0.55,0.42,0.50 and 0.99 μg/L（x2 =66.48,P ＜ 0.01）,the GM of 1-hydroxypyrene in the groups were 0.77,0.64,1.00,0.84,0.84 and 0.57 μg/L（x2 =51.48,P ＜0.01）,respectively.Conclusion The distribution of monohydroxy metabolites levels in urine of general population were different,it provided a basic data for the further study of polycyclic aromatic hydrocarbons biomonitoring in the population.

关 键 词：尿 横断面研究 多环芳烃 羟基萘 羟基菲 羟基芘 

分 类 号：R114[医药卫生—卫生毒理学]