清肠化湿治疗溃疡性结肠炎疗效及细胞因子变化研究  

Study of Effect of Qingchang Huashi Treating Ulcerative Colitis and Change of Cytokine

作　　者：梁梅荣[1] 

机构地区：[1]胜利石油管理局胜利医院,山东东营257000

出　　处：《山东中医杂志》2014年第2期96-98,共3页Shandong Journal of Traditional Chinese Medicine

摘　　要：目的:探析清肠化湿治疗溃疡性结肠炎的临床效果和对细胞因子的影响。方法:130例溃疡性结肠炎患者随机分组,对照组65例予美沙拉嗪口服,治疗组65例予清肠化湿方口服并配合灌肠方灌肠治疗,疗程1个月,比较两组的临床效果和血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、白细胞介素-1(IL-1)的变化。结果:治疗组总有效率显著高于对照组(95.4%比81.5%,P<0.05);两组细胞因子水平均显著下降,但同期相比治疗组血清IL-8、IL-1、TNF-α下降幅度显著高于对照组(P<0.05);治疗组对主要临床症状的改善优于对照组(P<0.05)。结论:清肠化湿治疗溃疡性结肠炎临床疗效确切,检测血清细胞因子可见下降幅度显著。Objective：To analye the clinical effect of Qingchang Huashi treating ulcerative colitis and the effect on cell factor. Methods：Choosing 130 patients with ulcerative colitis to randomly divided into two groups,and 65 cases each group. Control group treated with Mesalazine,and treatment group treated Qingchang Huashi prescription,and combined with enema treatment. After one months treatment,compare the clinical effect and change of serum TNF-α,IL-8 and IL-1 of two groups. Results：The total effective rate in treatment group was significantly higher than control group（95.4% vs 81.5% ,P〈0.05）and cytokine levels in the two group were decreased significantly,but, compared to the same period,serum IL-8,IL-1,TNF-α of treatment group declined significantly higher than control group（P〈0.05）. The improvement of the main clinical symptoms of treatment group was better than that of control group（P〈0.05）. Conclusion ：The clinical effect of Qingchang Huashi in the treatment of ulcerative colitis is definite,and serum cytokines decrease significantly.

关 键 词：溃疡性结肠炎 清肠化湿方 灌肠方 细胞因子 疗效观察 

分 类 号：R259.746.2[医药卫生—中西医结合]