乙烯利对小鼠生殖能力的影响  

Study on the reproductive toxicity of ethephon in mice

作　　者：杨治峰[1,2] 薄存香[1] 刘永霞[1] 谢琳[1] 戈扬[1] 张振玲[1] 

机构地区：[1]山东省医学科学院,山东省职业卫生与职业病防治研究院,山东省济南市250062 [2]济南大学,山东省医学科学院医学与生命科学学院

出　　处：《职业与健康》2014年第3期307-308,共2页Occupation and Health

基　　金：山东省自然科学基金项目(项目编号:ZR2010CL003)

摘　　要：目的研究乙烯利对小鼠生殖能力的影响。方法选用乙烯利作为染毒药物,实验设阴性对照组(0 mg/kg)、低剂量组(85 mg/kg)、中剂量组(170 mg/kg)和高剂量组(340 mg/kg),雄鼠经口染毒14 d,于首次给药第15天起以1∶1与雌鼠合笼。于合笼后第21天以颈椎脱臼处死雌鼠,剖腹检查确定受孕情况并计算生育仔鼠数。于首次给药第28天后用颈椎脱臼法处死雄鼠,观察乙烯利对雄鼠精子运动率的影响。结果高剂量组雌鼠受孕率与阴性对照组比较明显降低(P<0.05);与阴性对照组相比,高剂量组精子计数明显减少(P<0.05);各剂量组精子活动率均低于阴性对照组(P<0.05)。结论乙烯利对雄性小鼠产生了一定的生殖毒作用。[ Objective ] To explore the influence of ethephon on the reproductive capacity of mice. [ Methods ] The male mice were exposed to ethephon, and were divided into four groups, which included the control group l0 mg/kg}, low dose group 185 mg/kg}, middle dose group 1170 mg/kg） and high dose group {340 mg/kg}. Male mice were treated with ethephon by gavage, once a day for 14 consecutive days. 15 days after the first gavage, the male mice were mated with female mice in the ratio of 1： 1. The female mice were killed by cervical vertebra dislocation on the 21st day after the first mating, to observe the pregnancy rate and the quanti- ty of offspring. The male mice were killed by cervical vertebra dislocation on the 28th day after the exposure, to analyze the effect of ethephon on sperm motility. [ Results ] The pregnancy rate of female mice in high dose group was significantly lower than that in the control group （ P 〈 0.05 ）, the sperm count of the male mice in high dose group was significantly less than that in the control group （ P 〈 0.05 }, and the sperm motility of all exposure groups was significantly lower than that in the control group （ P 〈 0.05 ）. [ Conclusion]The study suggests that ethephon has reproductive toxicity in male mice.

关 键 词：乙烯利 小鼠 受孕率 毒性 

分 类 号：R114[医药卫生—卫生毒理学]