米索前列醇与盐酸丁卡因胶浆用于10~12周钳刮术的临床观察  

Efficacy of misoprostol and tetracaine hydrochloride mucilage on the pain control in curettage procedure

作　　者：杨春玲 朱志红 李颖 杨春香 

机构地区：[1]抚宁县计划生育技术服务站,河北秦皇岛066300 [2]抚宁县中医院,河北秦皇岛066300

出　　处：《中国性科学》2014年第1期36-38,共3页Chinese Journal of Human Sexuality

基　　金：河北省人口计生委2013年科研计划指令课题(2013-A27)

摘　　要：目的：比较米索前列醇单独使用与配伍盐酸丁卡因胶浆用于10-12周钳刮术中镇痛、宫颈松弛度、药物副反应等临床效果观察.方法：选择100例B超提示宫内孕10-12周自愿要求行钳刮术、无手术禁忌症、年龄在18-40岁妊娠妇女,随机分成A、B两组;A组于钳刮术前3h、1.5h分别舌下含服米索前列醇200μg,术前2-3min宫颈管内注入盐酸丁卡因胶浆1支后手术;B组于钳刮术前3h口服及阴道用米索前列醇分别400μg、200μg后手术.结果：A、B两组对比宫颈松弛度总有效率无明显差异,而显效率有明显差异（P〈0.01）,术中A、B两组总镇痛效果无明显差异（P〉0.05）,但A组无痛率明显高于B组,有统计学差异（P〈0.05）.A组副反应明显低于B组（P〈0.05）.结论：舌下含服米索前列醇配伍盐酸丁卡因胶浆用于钳刮术镇痛效果好,使用米索前列醇剂量小,药物副反应少,减少阴道操作带来的不便,更易于受术者接受,适合在基层临床应用.Objectives： To investigate the efficacy of misoprostol combined with tetracaine hydrochloride mucilage in the curettage procedure and to compare the analgesic effect, cervical laxity efficiency and adverse drug reactions. Method： 100 pregnant women, aging 18 ~ 40 years old, who had 10 -12 weeks＇ intrauterine pregnancies confirmed by B - mode ultrasound and voluntarily accepted curettage without surgical contraindications were se- lectad and randomly divided into Group A and Group B. The subjects in Group A were administered 200 ug of miso- prostol snblingually 3 hours and 1.5 hours before surgery and was injected tetracaine hydrocbloride mucilage into the cervical canal 2 - 3 minutes before the surgery. The subjects in Group B were given oral administration of 400 ug of misoprostol and 200 ug in the vagina 3 hours before the surgery. Results： The cervical laxity of the subjects in the two groups showed no significant difference , while the effectiveness differed significantly （ P 〈 0. 01 ）. Moreover, there was no significant difference in the analgesic effect of the two groups （ P 〉 0.05）, while the painless rate of Group A was significantly higher than that of Group B （P 〈 0. 05）. The adverse drug reaction rate of Group A was lower than that of Group B （P 〈 0. 05 ）. Conclusion ： Sublingual administration of misoprostol combined with tetracaine hydrochloride mucilage has better analgesic effect and less adverse drug reaction in curettage. Smaller amount of misoprotol is needed in the procedure, which can be convinient and time - saving.

关 键 词：米索前列醇 盐酸丁卡因胶浆 宫颈松弛度 镇痛效果 药物副反应 

分 类 号：R167[医药卫生—公共卫生与预防医学]