药物洗脱球囊的临床应用进展与展望  

Progress and Prospects in Clinical Application of Drug-Eluting Balloon

作　　者：杨士伟[1] 周玉杰[1] 

机构地区：[1]首都医科大学附属北京安贞医院心内科,北京100029

出　　处：《心血管病学进展》2014年第1期8-13,共6页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81100143);北京市教委重点项目(KZ201110025031);首都临床特色应用研究重点项目(Z0005190042811);北京市科技新星(Z121107002512053)

摘　　要：支架内再狭窄的最佳治疗手段目前尚不明确。我们围绕药物洗脱球囊的发展历史、有效性与安全性进行综述。文献主要来自2001年一2013年11月发表的随机对照试验及相关资料。结果显示，药物洗脱球囊有望成为支架内再狭窄、分又病变和小血管病变等多种情况的新的治疗手段。但其有效性和安全性仍需更多大样本、随机、对照临床试验的验证。The optimal treatment for in-stent restenosis is currently unclear. We performed this systematic review of the history, effect and safety of drug-eluting balloon （DEB）. Randomised clinical trials comparing DEB with a control treatment （ plain balloon angioplasty or drug-eluting stents） were identified through a literature search from 2001 through November 2013. We find that DEB is a promising treat ment option in multiple situations, including in-stent restenosis, bifurcation lesions, small vessel lesions, etc. But more large-scale random ised controlled clinical trials are needed to confirm it＇s effect and safety.

关 键 词：药物洗脱球囊 支架内再狭窄 分叉病变 小血管病变 

分 类 号：R541.4[医药卫生—心血管疾病]